Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045871034> ?p ?o ?g. }
- W2045871034 endingPage "417" @default.
- W2045871034 startingPage "409" @default.
- W2045871034 abstract "Antiretroviral-therapy rollout in resource-poor countries is often associated with limited, if any, HIV-RNA monitoring. The effect of variable monitoring on the emergence of resistance after therapy with commonly used drug combinations was assessed by systematic review of studies reporting resistance in patients infected with HIV with a CD4 count of fewer than 200 cells per μL treated with two nucleoside analogues (including a thymidine analogue) and a non-nucleoside reverse transcriptase inhibitor. 8376 patients from eight cohorts and two prospective studies were analysed. Resistance at virological failure to non-nucleoside reverse transcriptase inhibitors at 48 weeks was 88·3% (95% CI 82·2–92·9) in infrequently monitored patients, compared with 61·0% (48·9–72·2) in frequently monitored patients (p<0·001). Lamivudine resistance was 80·5% (72·9–86·8) and 40·3% (29·1–52·2) in infrequently and frequently monitored patients, respectively (p<0·001); the prevalence of at least one thymidine analogue mutation was 27·8% (21·2–35·2) and 12·1% (5·9–21·4), respectively (p<0·001). Genotypic resistance at 48 weeks to lamivudine, nucleoside reverse transcriptase inhibitors (thymidine analogue mutations), and non-nucleoside reverse transcriptase inhibitors appears substantially higher in less frequently monitored patients. This Review highlights the need for cheap point-of-care viral-load tests to identify early viral failures and limit the emergence of resistance." @default.
- W2045871034 created "2016-06-24" @default.
- W2045871034 creator A5015958019 @default.
- W2045871034 creator A5017146733 @default.
- W2045871034 creator A5020901993 @default.
- W2045871034 creator A5036869978 @default.
- W2045871034 creator A5044801510 @default.
- W2045871034 creator A5047438814 @default.
- W2045871034 creator A5052132429 @default.
- W2045871034 creator A5059988483 @default.
- W2045871034 creator A5060462160 @default.
- W2045871034 creator A5060727664 @default.
- W2045871034 date "2009-07-01" @default.
- W2045871034 modified "2023-10-16" @default.
- W2045871034 title "Virological monitoring and resistance to first-line highly active antiretroviral therapy in adults infected with HIV-1 treated under WHO guidelines: a systematic review and meta-analysis" @default.
- W2045871034 cites W1743324003 @default.
- W2045871034 cites W1854681245 @default.
- W2045871034 cites W1966805252 @default.
- W2045871034 cites W1967825197 @default.
- W2045871034 cites W2000442546 @default.
- W2045871034 cites W2005881305 @default.
- W2045871034 cites W2016682266 @default.
- W2045871034 cites W2022805318 @default.
- W2045871034 cites W2047734031 @default.
- W2045871034 cites W2052332986 @default.
- W2045871034 cites W2053786745 @default.
- W2045871034 cites W2056779298 @default.
- W2045871034 cites W2068751404 @default.
- W2045871034 cites W2080734162 @default.
- W2045871034 cites W2083477796 @default.
- W2045871034 cites W2088250967 @default.
- W2045871034 cites W2096686776 @default.
- W2045871034 cites W2102741140 @default.
- W2045871034 cites W2103866977 @default.
- W2045871034 cites W2110937893 @default.
- W2045871034 cites W2117579170 @default.
- W2045871034 cites W2122280827 @default.
- W2045871034 cites W2124801504 @default.
- W2045871034 cites W2133166320 @default.
- W2045871034 cites W2141776019 @default.
- W2045871034 cites W2149573022 @default.
- W2045871034 cites W2149927953 @default.
- W2045871034 cites W2150369519 @default.
- W2045871034 cites W2153529108 @default.
- W2045871034 cites W2155449170 @default.
- W2045871034 cites W2165762745 @default.
- W2045871034 cites W2168405519 @default.
- W2045871034 cites W2170578204 @default.
- W2045871034 cites W2248727186 @default.
- W2045871034 cites W4251271298 @default.
- W2045871034 doi "https://doi.org/10.1016/s1473-3099(09)70136-7" @default.
- W2045871034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19555900" @default.
- W2045871034 hasPublicationYear "2009" @default.
- W2045871034 type Work @default.
- W2045871034 sameAs 2045871034 @default.
- W2045871034 citedByCount "229" @default.
- W2045871034 countsByYear W20458710342012 @default.
- W2045871034 countsByYear W20458710342013 @default.
- W2045871034 countsByYear W20458710342014 @default.
- W2045871034 countsByYear W20458710342015 @default.
- W2045871034 countsByYear W20458710342016 @default.
- W2045871034 countsByYear W20458710342017 @default.
- W2045871034 countsByYear W20458710342018 @default.
- W2045871034 countsByYear W20458710342019 @default.
- W2045871034 countsByYear W20458710342020 @default.
- W2045871034 countsByYear W20458710342021 @default.
- W2045871034 countsByYear W20458710342022 @default.
- W2045871034 countsByYear W20458710342023 @default.
- W2045871034 crossrefType "journal-article" @default.
- W2045871034 hasAuthorship W2045871034A5015958019 @default.
- W2045871034 hasAuthorship W2045871034A5017146733 @default.
- W2045871034 hasAuthorship W2045871034A5020901993 @default.
- W2045871034 hasAuthorship W2045871034A5036869978 @default.
- W2045871034 hasAuthorship W2045871034A5044801510 @default.
- W2045871034 hasAuthorship W2045871034A5047438814 @default.
- W2045871034 hasAuthorship W2045871034A5052132429 @default.
- W2045871034 hasAuthorship W2045871034A5059988483 @default.
- W2045871034 hasAuthorship W2045871034A5060462160 @default.
- W2045871034 hasAuthorship W2045871034A5060727664 @default.
- W2045871034 hasConcept C104317684 @default.
- W2045871034 hasConcept C114851261 @default.
- W2045871034 hasConcept C126322002 @default.
- W2045871034 hasConcept C142462285 @default.
- W2045871034 hasConcept C156719811 @default.
- W2045871034 hasConcept C159047783 @default.
- W2045871034 hasConcept C182707283 @default.
- W2045871034 hasConcept C2522874641 @default.
- W2045871034 hasConcept C2776543447 @default.
- W2045871034 hasConcept C2777333352 @default.
- W2045871034 hasConcept C2777351918 @default.
- W2045871034 hasConcept C2777447569 @default.
- W2045871034 hasConcept C2777869810 @default.
- W2045871034 hasConcept C2779889181 @default.
- W2045871034 hasConcept C2780216070 @default.
- W2045871034 hasConcept C2780593183 @default.
- W2045871034 hasConcept C2780727368 @default.
- W2045871034 hasConcept C2909970146 @default.
- W2045871034 hasConcept C2993143319 @default.