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- W2045874726 abstract "An efficient process was developed for the manufacture of MSA100, a serotonin receptor antagonist, via a five-step synthetic route furnishing a high quality of active pharmaceutical ingredient. Highlights of this synthesis include: (1) replacing carcinogenic methyl iodide with methyl p-toluenesulfonate as the methylating reagent; (2) a hydrogenation protocol with optimized temperature, pressure, and mass-transfer conditions that avoided one side product and reduced the other one effectively; (3) chemical resolution employing D-camphoric acid in a mixed-solvent system; (4) amidation under anhydrous conditions for controlling a Michael adduct impurity; and (5) plausible mechanisms for the formation of side products." @default.
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- W2045874726 date "2014-12-18" @default.
- W2045874726 modified "2023-09-26" @default.
- W2045874726 title "Development of a Scalable Synthesis of a Serotonin Receptor Antagonist" @default.
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- W2045874726 doi "https://doi.org/10.1021/op5003402" @default.
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