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- W2045881502 abstract "To mimic amphiphilic α-helices, a new scaffold was designed based on a bis-benzamide that places four side-chain functional groups found at the i, i+2, i+5, and i+7 positions of a helix. Its two hydrogen bonds fix the conformation and provide accurate bifacial arrangement of the four substituents, simultaneously representing two opposing helical sides. An efficient synthetic route was achieved for the construction of bis-benzamides, and their superior α-helix mimicry was confirmed by X-ray crystallography." @default.
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- W2045881502 date "2009-08-31" @default.
- W2045881502 modified "2023-10-03" @default.
- W2045881502 title "Novel Amphiphilic α-Helix Mimetics Based on a Bis-benzamide Scaffold" @default.
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- W2045881502 doi "https://doi.org/10.1021/ol901785v" @default.
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