Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045882584> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2045882584 endingPage "397" @default.
- W2045882584 startingPage "385" @default.
- W2045882584 abstract "Chagas' disease is a parasitic chronic condition affecting several million people in Latin America. Two drugs are used in the chemotherapy of Chagas' disease: nifurtimox (Nfx) and benznidazole (Bz). Both are nitroderivatives whose deleterious effects are related to their reductive biotransformation. In this work we report that rat ovaries exhibited Bz and Nfx nitroreductase activity. The Bz nitroreductase was only found in the mitochondrial fraction and was partially inhibited by CO. The Nfx nitroreductase activity was maximal in ovarian mitochondria but was also present in microsomes and in the cytosol. The microsomal enzyme was completely inhibited by CO while that in mitochondria was only partially inhibited by CO. The cytosolic activity only proceeded using hypoxanthine as substrate and was inhibited by allopurinol. The cytosolic activity was able to proceed in part under oxygen. All the other Bz or Nfx nitroreductases were completely inhibited by atmospheric oxygen. The potential participation of cytochrome P450, flavoenzymes, iron-sulfur-protein, and xanthinooxidase in both nitroreductive processes is discussed. The administration of either Nfx or Bz to female rats produced ultrastructural degenerative effects in the different cell types of ovaries. Specific alterations such as swelling, disruption, disorganization, and loss of matrix components were observed in ovarian mitochondria. These alterations occurred irrespectively of the ovarian cycle stage. The potential reproductive toxicological consequences of Bz or Nfx administration are analyzed." @default.
- W2045882584 created "2016-06-24" @default.
- W2045882584 creator A5012561202 @default.
- W2045882584 creator A5017125754 @default.
- W2045882584 creator A5047842830 @default.
- W2045882584 creator A5055112670 @default.
- W2045882584 creator A5087050797 @default.
- W2045882584 date "1989-06-01" @default.
- W2045882584 modified "2023-10-18" @default.
- W2045882584 title "Ultrastructural alterations in ovaries from nifurtimox or benznidazole-treated rats: Their relation to ovarian nitroreductive biotransformation of both drugs" @default.
- W2045882584 cites W1979973366 @default.
- W2045882584 cites W1988568919 @default.
- W2045882584 cites W2009361664 @default.
- W2045882584 cites W2019126938 @default.
- W2045882584 cites W2023564566 @default.
- W2045882584 cites W2034912738 @default.
- W2045882584 cites W2045284925 @default.
- W2045882584 cites W2045297967 @default.
- W2045882584 cites W2081404902 @default.
- W2045882584 cites W2142596760 @default.
- W2045882584 cites W2143187631 @default.
- W2045882584 doi "https://doi.org/10.1016/0014-4800(89)90047-6" @default.
- W2045882584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2721655" @default.
- W2045882584 hasPublicationYear "1989" @default.
- W2045882584 type Work @default.
- W2045882584 sameAs 2045882584 @default.
- W2045882584 citedByCount "17" @default.
- W2045882584 countsByYear W20458825842013 @default.
- W2045882584 countsByYear W20458825842015 @default.
- W2045882584 countsByYear W20458825842021 @default.
- W2045882584 crossrefType "journal-article" @default.
- W2045882584 hasAuthorship W2045882584A5012561202 @default.
- W2045882584 hasAuthorship W2045882584A5017125754 @default.
- W2045882584 hasAuthorship W2045882584A5047842830 @default.
- W2045882584 hasAuthorship W2045882584A5055112670 @default.
- W2045882584 hasAuthorship W2045882584A5087050797 @default.
- W2045882584 hasConcept C136764020 @default.
- W2045882584 hasConcept C181199279 @default.
- W2045882584 hasConcept C185592680 @default.
- W2045882584 hasConcept C2776171842 @default.
- W2045882584 hasConcept C2777625466 @default.
- W2045882584 hasConcept C2781049234 @default.
- W2045882584 hasConcept C2781326480 @default.
- W2045882584 hasConcept C27881333 @default.
- W2045882584 hasConcept C28859421 @default.
- W2045882584 hasConcept C41008148 @default.
- W2045882584 hasConcept C55493867 @default.
- W2045882584 hasConcept C71928629 @default.
- W2045882584 hasConcept C86803240 @default.
- W2045882584 hasConcept C87644729 @default.
- W2045882584 hasConcept C98274493 @default.
- W2045882584 hasConcept C98539663 @default.
- W2045882584 hasConceptScore W2045882584C136764020 @default.
- W2045882584 hasConceptScore W2045882584C181199279 @default.
- W2045882584 hasConceptScore W2045882584C185592680 @default.
- W2045882584 hasConceptScore W2045882584C2776171842 @default.
- W2045882584 hasConceptScore W2045882584C2777625466 @default.
- W2045882584 hasConceptScore W2045882584C2781049234 @default.
- W2045882584 hasConceptScore W2045882584C2781326480 @default.
- W2045882584 hasConceptScore W2045882584C27881333 @default.
- W2045882584 hasConceptScore W2045882584C28859421 @default.
- W2045882584 hasConceptScore W2045882584C41008148 @default.
- W2045882584 hasConceptScore W2045882584C55493867 @default.
- W2045882584 hasConceptScore W2045882584C71928629 @default.
- W2045882584 hasConceptScore W2045882584C86803240 @default.
- W2045882584 hasConceptScore W2045882584C87644729 @default.
- W2045882584 hasConceptScore W2045882584C98274493 @default.
- W2045882584 hasConceptScore W2045882584C98539663 @default.
- W2045882584 hasIssue "3" @default.
- W2045882584 hasLocation W20458825841 @default.
- W2045882584 hasLocation W20458825842 @default.
- W2045882584 hasOpenAccess W2045882584 @default.
- W2045882584 hasPrimaryLocation W20458825841 @default.
- W2045882584 hasRelatedWork W1963689126 @default.
- W2045882584 hasRelatedWork W1977200340 @default.
- W2045882584 hasRelatedWork W1979973366 @default.
- W2045882584 hasRelatedWork W2045882584 @default.
- W2045882584 hasRelatedWork W2055067652 @default.
- W2045882584 hasRelatedWork W2062585138 @default.
- W2045882584 hasRelatedWork W2111548063 @default.
- W2045882584 hasRelatedWork W2418033361 @default.
- W2045882584 hasRelatedWork W2440142880 @default.
- W2045882584 hasRelatedWork W2465886388 @default.
- W2045882584 hasVolume "50" @default.
- W2045882584 isParatext "false" @default.
- W2045882584 isRetracted "false" @default.
- W2045882584 magId "2045882584" @default.
- W2045882584 workType "article" @default.