FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045900632> ?p ?o ?g. }

• W2045900632 abstract "The uptake of polyunsaturated fatty acids by rat hepatoma cells and fetal hepatocytes has been studied using albumin and alpha-fetoprotein (AFP) as carrier proteins. Both types of cells took up linoleic (18:2(n-6)) and linolenic (18:3(n-3)) fatty acids at the same rate when they were added complexed either to albumin or AFP at a 1:1 molar ratio. At 37 degrees C a greater incorporation of arachidonic acid (20:4(n-6)) and mainly docosahexaenoic acid (22:6(n-3)) was observed when these acids were bound to albumin (6.5 nmol 20:4(n-6); 6.4 nmol 22:6(n-3) /million cells) as compared to AFP (5.5 nmol 20:4(n-6); 4.3 nmol 22:6(n-3)/million cells). The 20:4(n-6) and 22:6(n-3) uptake seems to be inversely related to the apparent association constants (k'a) between these fatty acids and both proteins (1.3 and 1.5 x 10(-7) M-1 20:4(n-6) and 22:6(n-3) for albumin; 6.4 and 54.0 x 10(-7) M-1 20:4(n-6) and 22:6(n-3) for AFP). Experiments carried out at 4 degrees C indicated that binding of 20:4(n-6) (0.83 nmol/million cells in presence of albumin; 2.16 nmol/million cells in presence of AFP) and 22:6(n-3) (0.83 nmol/million cells in presence of albumin; 1.32 nmol/million cells in presence of AFP) by cell membranes was also inversely related to the k'a of these proteins. At 4 degrees C, the k'a of AFP and albumin for 20:4(n-6) and 22:6(n-3) changed considerably (12.7 and 9.6 x 10(-7) M-1 20:4(n-6) and 22:6(n-3) for albumin; 3.9 and 14.6 x 10(-7) M-1 20:4(n-6) and 22:6(n-3) for AFP) with respect to the k'a calculated at 37 degrees C. Hence, k'a values were higher for albumin and lower for AFP than the corresponding values at 37 degrees C. It was concluded that uptake by cells and interaction of fatty acids with cell membranes depend mainly on the k'a of fatty acids and carrier proteins at equilibrium." @default.
• W2045900632 created "2016-06-24" @default.
• W2045900632 creator A5015858150 @default.
• W2045900632 creator A5028144512 @default.
• W2045900632 creator A5040935744 @default.
• W2045900632 creator A5050926473 @default.
• W2045900632 creator A5059782439 @default.
• W2045900632 date "1991-10-01" @default.
• W2045900632 modified "2023-10-18" @default.
• W2045900632 title "Effect of α-fetoprotein and albumin on the uptake of polyunsaturated fatty acids by rat hepatoma cells and fetal rat hepatocytes" @default.
• W2045900632 cites W1197462242 @default.
• W2045900632 cites W1486298457 @default.
• W2045900632 cites W1489376146 @default.
• W2045900632 cites W1505290993 @default.
• W2045900632 cites W1519656691 @default.
• W2045900632 cites W1526942240 @default.
• W2045900632 cites W1537865659 @default.
• W2045900632 cites W1571945051 @default.
• W2045900632 cites W1576334750 @default.
• W2045900632 cites W1592584230 @default.
• W2045900632 cites W1873570378 @default.
• W2045900632 cites W1966722575 @default.
• W2045900632 cites W1979466599 @default.
• W2045900632 cites W2002483866 @default.
• W2045900632 cites W2008278365 @default.
• W2045900632 cites W2010263336 @default.
• W2045900632 cites W2043671029 @default.
• W2045900632 cites W2045006357 @default.
• W2045900632 cites W2049093814 @default.
• W2045900632 cites W2059656737 @default.
• W2045900632 cites W2068556075 @default.
• W2045900632 cites W2068779149 @default.
• W2045900632 cites W2089955310 @default.
• W2045900632 cites W2150509573 @default.
• W2045900632 cites W2151959697 @default.
• W2045900632 cites W2181700870 @default.
• W2045900632 cites W2213294326 @default.
• W2045900632 cites W2394660565 @default.
• W2045900632 cites W985575737 @default.
• W2045900632 doi "https://doi.org/10.1016/0005-2760(91)90157-d" @default.
• W2045900632 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1720022" @default.
• W2045900632 hasPublicationYear "1991" @default.
• W2045900632 type Work @default.
• W2045900632 sameAs 2045900632 @default.
• W2045900632 citedByCount "9" @default.
• W2045900632 countsByYear W20459006322013 @default.
• W2045900632 countsByYear W20459006322014 @default.
• W2045900632 countsByYear W20459006322021 @default.
• W2045900632 crossrefType "journal-article" @default.
• W2045900632 hasAuthorship W2045900632A5015858150 @default.
• W2045900632 hasAuthorship W2045900632A5028144512 @default.
• W2045900632 hasAuthorship W2045900632A5040935744 @default.
• W2045900632 hasAuthorship W2045900632A5050926473 @default.
• W2045900632 hasAuthorship W2045900632A5059782439 @default.
• W2045900632 hasConcept C126322002 @default.
• W2045900632 hasConcept C134018914 @default.
• W2045900632 hasConcept C153911025 @default.
• W2045900632 hasConcept C165616093 @default.
• W2045900632 hasConcept C181199279 @default.
• W2045900632 hasConcept C185592680 @default.
• W2045900632 hasConcept C19038510 @default.
• W2045900632 hasConcept C202751555 @default.
• W2045900632 hasConcept C2776125364 @default.
• W2045900632 hasConcept C2776200302 @default.
• W2045900632 hasConcept C2777171753 @default.
• W2045900632 hasConcept C2778019345 @default.
• W2045900632 hasConcept C2778078955 @default.
• W2045900632 hasConcept C2780624289 @default.
• W2045900632 hasConcept C2780809830 @default.
• W2045900632 hasConcept C543025807 @default.
• W2045900632 hasConcept C55493867 @default.
• W2045900632 hasConcept C71924100 @default.
• W2045900632 hasConcept C86803240 @default.
• W2045900632 hasConceptScore W2045900632C126322002 @default.
• W2045900632 hasConceptScore W2045900632C134018914 @default.
• W2045900632 hasConceptScore W2045900632C153911025 @default.
• W2045900632 hasConceptScore W2045900632C165616093 @default.
• W2045900632 hasConceptScore W2045900632C181199279 @default.
• W2045900632 hasConceptScore W2045900632C185592680 @default.
• W2045900632 hasConceptScore W2045900632C19038510 @default.
• W2045900632 hasConceptScore W2045900632C202751555 @default.
• W2045900632 hasConceptScore W2045900632C2776125364 @default.
• W2045900632 hasConceptScore W2045900632C2776200302 @default.
• W2045900632 hasConceptScore W2045900632C2777171753 @default.
• W2045900632 hasConceptScore W2045900632C2778019345 @default.
• W2045900632 hasConceptScore W2045900632C2778078955 @default.
• W2045900632 hasConceptScore W2045900632C2780624289 @default.
• W2045900632 hasConceptScore W2045900632C2780809830 @default.
• W2045900632 hasConceptScore W2045900632C543025807 @default.
• W2045900632 hasConceptScore W2045900632C55493867 @default.
• W2045900632 hasConceptScore W2045900632C71924100 @default.
• W2045900632 hasConceptScore W2045900632C86803240 @default.
• W2045900632 hasLocation W20459006321 @default.
• W2045900632 hasLocation W20459006322 @default.
• W2045900632 hasOpenAccess W2045900632 @default.
• W2045900632 hasPrimaryLocation W20459006321 @default.
• W2045900632 hasRelatedWork W2000198760 @default.
• W2045900632 hasRelatedWork W2004534398 @default.
• W2045900632 hasRelatedWork W2012916399 @default.
• W2045900632 hasRelatedWork W2045678716 @default.

• next