Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045902488> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2045902488 abstract "Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, ILPARP is an enzyme involved in sensing single-stranded DNA breaks and plays a critical role in the organization of DNA damage repair. Several PARP inhibitors have been developed for clinical use, particularly in breast and ovarian cancers with BRCA mutations. Despite the scientific rationale and promising early clinical results with PARP inhibitors, more advanced clinical trials in breast cancer have been disappointing. One of the questions arising from these trials is to better understand why the PARP inhibitors failed. We used a window-chamber system in mice to image the distribution and function of model PARP inhibitors such as AZD2281-Bodipy. Specifically, we measured the kinetics of vascular, cellular, and subcellular uptake and distribution of AZD2281-Bodipy in breast (MDA-MB-231, MDA-MB-436) and ovarian (OVCAR429, A2780) tumors over time. Additionally, using the fluorescently-labeled inhibitor, we were able to examine the heterogeneity of AZD2281 localization in single cancer cells in vivo. Our data provide the first example of single-cell distribution of fluorescent small molecule inhibitors. When coupled with reporter cell lines (e.g. for apoptosis, DNA damage, autophagy, and senescence), this approach will be a powerful tool to understand drug action in vivo.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4293. doi:1538-7445.AM2012-4293" @default.
- W2045902488 created "2016-06-24" @default.
- W2045902488 creator A5031991453 @default.
- W2045902488 creator A5037263558 @default.
- W2045902488 creator A5067255019 @default.
- W2045902488 creator A5072428132 @default.
- W2045902488 creator A5081117793 @default.
- W2045902488 date "2012-04-15" @default.
- W2045902488 modified "2023-09-26" @default.
- W2045902488 title "Abstract 4293: In vivo imaging and tracking of a PARP inhibitor at single-cell resolution" @default.
- W2045902488 doi "https://doi.org/10.1158/1538-7445.am2012-4293" @default.
- W2045902488 hasPublicationYear "2012" @default.
- W2045902488 type Work @default.
- W2045902488 sameAs 2045902488 @default.
- W2045902488 citedByCount "0" @default.
- W2045902488 crossrefType "proceedings-article" @default.
- W2045902488 hasAuthorship W2045902488A5031991453 @default.
- W2045902488 hasAuthorship W2045902488A5037263558 @default.
- W2045902488 hasAuthorship W2045902488A5067255019 @default.
- W2045902488 hasAuthorship W2045902488A5072428132 @default.
- W2045902488 hasAuthorship W2045902488A5081117793 @default.
- W2045902488 hasConcept C121608353 @default.
- W2045902488 hasConcept C126322002 @default.
- W2045902488 hasConcept C143425029 @default.
- W2045902488 hasConcept C182979987 @default.
- W2045902488 hasConcept C185592680 @default.
- W2045902488 hasConcept C207001950 @default.
- W2045902488 hasConcept C2779138821 @default.
- W2045902488 hasConcept C2779962180 @default.
- W2045902488 hasConcept C502942594 @default.
- W2045902488 hasConcept C530470458 @default.
- W2045902488 hasConcept C54355233 @default.
- W2045902488 hasConcept C552990157 @default.
- W2045902488 hasConcept C55493867 @default.
- W2045902488 hasConcept C71924100 @default.
- W2045902488 hasConcept C82381507 @default.
- W2045902488 hasConcept C86803240 @default.
- W2045902488 hasConcept C96232424 @default.
- W2045902488 hasConceptScore W2045902488C121608353 @default.
- W2045902488 hasConceptScore W2045902488C126322002 @default.
- W2045902488 hasConceptScore W2045902488C143425029 @default.
- W2045902488 hasConceptScore W2045902488C182979987 @default.
- W2045902488 hasConceptScore W2045902488C185592680 @default.
- W2045902488 hasConceptScore W2045902488C207001950 @default.
- W2045902488 hasConceptScore W2045902488C2779138821 @default.
- W2045902488 hasConceptScore W2045902488C2779962180 @default.
- W2045902488 hasConceptScore W2045902488C502942594 @default.
- W2045902488 hasConceptScore W2045902488C530470458 @default.
- W2045902488 hasConceptScore W2045902488C54355233 @default.
- W2045902488 hasConceptScore W2045902488C552990157 @default.
- W2045902488 hasConceptScore W2045902488C55493867 @default.
- W2045902488 hasConceptScore W2045902488C71924100 @default.
- W2045902488 hasConceptScore W2045902488C82381507 @default.
- W2045902488 hasConceptScore W2045902488C86803240 @default.
- W2045902488 hasConceptScore W2045902488C96232424 @default.
- W2045902488 hasLocation W20459024881 @default.
- W2045902488 hasOpenAccess W2045902488 @default.
- W2045902488 hasPrimaryLocation W20459024881 @default.
- W2045902488 hasRelatedWork W2058694977 @default.
- W2045902488 hasRelatedWork W2090266756 @default.
- W2045902488 hasRelatedWork W2101012300 @default.
- W2045902488 hasRelatedWork W2335437264 @default.
- W2045902488 hasRelatedWork W2338647065 @default.
- W2045902488 hasRelatedWork W2549651109 @default.
- W2045902488 hasRelatedWork W2562402105 @default.
- W2045902488 hasRelatedWork W2612722949 @default.
- W2045902488 hasRelatedWork W2740388256 @default.
- W2045902488 hasRelatedWork W2741762034 @default.
- W2045902488 hasRelatedWork W2807169993 @default.
- W2045902488 hasRelatedWork W2887692713 @default.
- W2045902488 hasRelatedWork W2896928359 @default.
- W2045902488 hasRelatedWork W2917635096 @default.
- W2045902488 hasRelatedWork W2992138944 @default.
- W2045902488 hasRelatedWork W3011487857 @default.
- W2045902488 hasRelatedWork W3049541627 @default.
- W2045902488 hasRelatedWork W3082662849 @default.
- W2045902488 hasRelatedWork W3083241313 @default.
- W2045902488 hasRelatedWork W3083494100 @default.
- W2045902488 isParatext "false" @default.
- W2045902488 isRetracted "false" @default.
- W2045902488 magId "2045902488" @default.
- W2045902488 workType "article" @default.