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• W2045904081 abstract "Drosophila putzig was identified as a member of the TRF2-DREF complex that is involved in core promoter selection. Additionally, putzig regulates Notch signaling, however independently of DREF. Here, we show that Putzig associates with the NURF complex. Loss of any NURF component including the NURF-specific subunit Nurf 301 impedes binding of Putzig to Notch target genes, suggesting that NURF recruits Putzig to these sites. Accordingly, Putzig can be copurified with any NURF member. Moreover, Nurf 301 mutants show reduced Notch target gene activity and enhance Notch mutant phenotypes. These data suggest a novel Putzig-NURF chromatin complex required for epigenetic activation of Notch targets." @default.
• W2045904081 created "2016-06-24" @default.
• W2045904081 creator A5023837853 @default.
• W2045904081 creator A5029583135 @default.
• W2045904081 date "2010-10-01" @default.
• W2045904081 modified "2023-10-05" @default.
• W2045904081 title "A Novel Pzg-NURF Complex Regulates Notch Target Gene Activity" @default.
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• W2045904081 doi "https://doi.org/10.1091/mbc.e10-03-0212" @default.
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