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• W2045921745 abstract "Tuberculosis has become a major health problem, in particular with the emergence of extremely drug resistant tuberculosis (XDRTB). In our search for new therapeutic leads against TB, we isolated a new triterpene (1) from the plant Rhus taitensis collected in Papua New Guinea. Tetrahydroxysqualene (1) was isolated using bioassay-guided fractionation of the methanolic extract of R. taitensis leaves and twigs. The structure of tetrahydroxysqualene (1) was elucidated on the basis of HRESIMS and 1D and 2D NMR spectra. Tetrahydroxysqualene (1) exhibited antituberculosis activity with an MIC of 10.0 μg/mL, while showing only modest cytotoxicity." @default.
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• W2045921745 date "2008-08-19" @default.
• W2045921745 modified "2023-09-23" @default.
• W2045921745 title "Tetrahdroxysqualene from <i>Rhus taitensis</i> Shows Antimycobacterial Activity against <i>Mycobacterium tuberculosis</i>" @default.
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• W2045921745 doi "https://doi.org/10.1021/np800082e" @default.
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