FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045925057> ?p ?o ?g. }

• W2045925057 endingPage "220" @default.
• W2045925057 startingPage "219" @default.
• W2045925057 abstract "We have previously localized a preeclampsia susceptibility locus on chromosome 2q22 in 34 Australian and New Zealand (AUS/NZL) families. Using an extended number of AUS/NZL families (n=74) we have now performed a comprehensive molecular genetics dissection of this locus.Identify causal genetic risk factors for preeclampsia at the 2q22 risk locus.To prioritize positional candidate genes for analysis we used a combination of bioinformatics, SNPing, whole-genome transcriptional profiling and proximity to the peak linkage signal. Prioritized genes were earmarked for exon-centric re-sequencing in 48 founder individuals from the 74 AUS/NZL families. All identified sequence variants were genotyped back in this extended familial cohort. Variants showing the strongest genetic association were genotyped in independent case-control cohorts from Australia (n=1095), Norway (n=3397) and Finland (n=1519), and in a large cohort of Mexican American families rich in quantitative cardiovascular disease (CVD) risk traits.We interrogated 1598 variants from 52 genes and identified four independent SNPs to be significantly associated with preeclampsia susceptibility in the 74 AUS/NZL families. These four SNPs reside in four novel preeclampsia candidate genes: LCT (rs2322659, p=0.002), LRP1B (rs35821928, p=0.0001), RND3 (rs115015150, p=0.002) and GCA (rs17783344, p=0.002). We could only replicate the LCT SNP association in the Australian case-control population (p=0.04, combined p=0.001). These four SNPs are however, significantly associated with several quantitative CVD risk traits such as oxidative stress indicators, inflammatory biomarkers and obesity risk factors.Previous independent studies have reported significant genetic associations with total cholesterol levels and obesity risk factors for variants within LCT and LRP1B, respectively. RND3 inhibits the biological activity of a downstream effector protein, ROCK, which is known to affect endothelial dysfunction, inflammation, oxidative stress and vascular re-modeling. Grancalcin (GCA) is known to impact the adhesive properties of fibronectin, a marker for endothelial vascular injury. To our knowledge, data from the current study present for the first time empirical evidence of possible shared genetic risk factors underlying both preeclampsia and other CVD-related traits." @default.
• W2045925057 created "2016-06-24" @default.
• W2045925057 creator A5004538115 @default.
• W2045925057 creator A5009288119 @default.
• W2045925057 creator A5012600661 @default.
• W2045925057 creator A5017431021 @default.
• W2045925057 creator A5023704619 @default.
• W2045925057 creator A5026959534 @default.
• W2045925057 creator A5027048775 @default.
• W2045925057 creator A5035957107 @default.
• W2045925057 creator A5049055474 @default.
• W2045925057 creator A5067068110 @default.
• W2045925057 creator A5069086952 @default.
• W2045925057 creator A5073224358 @default.
• W2045925057 creator A5077342690 @default.
• W2045925057 creator A5078239405 @default.
• W2045925057 creator A5084039553 @default.
• W2045925057 creator A5087859639 @default.
• W2045925057 date "2012-07-01" @default.
• W2045925057 modified "2023-09-27" @default.
• W2045925057 title "OS077. The chromosome 2q22 preeclampsia susceptibility locus reveals shared novel risk factors for CVD" @default.
• W2045925057 doi "https://doi.org/10.1016/j.preghy.2012.04.078" @default.
• W2045925057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26105291" @default.
• W2045925057 hasPublicationYear "2012" @default.
• W2045925057 type Work @default.
• W2045925057 sameAs 2045925057 @default.
• W2045925057 citedByCount "4" @default.
• W2045925057 countsByYear W20459250572020 @default.
• W2045925057 countsByYear W20459250572021 @default.
• W2045925057 countsByYear W20459250572022 @default.
• W2045925057 crossrefType "journal-article" @default.
• W2045925057 hasAuthorship W2045925057A5004538115 @default.
• W2045925057 hasAuthorship W2045925057A5009288119 @default.
• W2045925057 hasAuthorship W2045925057A5012600661 @default.
• W2045925057 hasAuthorship W2045925057A5017431021 @default.
• W2045925057 hasAuthorship W2045925057A5023704619 @default.
• W2045925057 hasAuthorship W2045925057A5026959534 @default.
• W2045925057 hasAuthorship W2045925057A5027048775 @default.
• W2045925057 hasAuthorship W2045925057A5035957107 @default.
• W2045925057 hasAuthorship W2045925057A5049055474 @default.
• W2045925057 hasAuthorship W2045925057A5067068110 @default.
• W2045925057 hasAuthorship W2045925057A5069086952 @default.
• W2045925057 hasAuthorship W2045925057A5073224358 @default.
• W2045925057 hasAuthorship W2045925057A5077342690 @default.
• W2045925057 hasAuthorship W2045925057A5078239405 @default.
• W2045925057 hasAuthorship W2045925057A5084039553 @default.
• W2045925057 hasAuthorship W2045925057A5087859639 @default.
• W2045925057 hasConcept C104317684 @default.
• W2045925057 hasConcept C106208931 @default.
• W2045925057 hasConcept C135763542 @default.
• W2045925057 hasConcept C139275648 @default.
• W2045925057 hasConcept C142870003 @default.
• W2045925057 hasConcept C153209595 @default.
• W2045925057 hasConcept C186413461 @default.
• W2045925057 hasConcept C197754878 @default.
• W2045925057 hasConcept C2908647359 @default.
• W2045925057 hasConcept C54355233 @default.
• W2045925057 hasConcept C60644358 @default.
• W2045925057 hasConcept C69991583 @default.
• W2045925057 hasConcept C71924100 @default.
• W2045925057 hasConcept C84597430 @default.
• W2045925057 hasConcept C86803240 @default.
• W2045925057 hasConcept C99454951 @default.
• W2045925057 hasConceptScore W2045925057C104317684 @default.
• W2045925057 hasConceptScore W2045925057C106208931 @default.
• W2045925057 hasConceptScore W2045925057C135763542 @default.
• W2045925057 hasConceptScore W2045925057C139275648 @default.
• W2045925057 hasConceptScore W2045925057C142870003 @default.
• W2045925057 hasConceptScore W2045925057C153209595 @default.
• W2045925057 hasConceptScore W2045925057C186413461 @default.
• W2045925057 hasConceptScore W2045925057C197754878 @default.
• W2045925057 hasConceptScore W2045925057C2908647359 @default.
• W2045925057 hasConceptScore W2045925057C54355233 @default.
• W2045925057 hasConceptScore W2045925057C60644358 @default.
• W2045925057 hasConceptScore W2045925057C69991583 @default.
• W2045925057 hasConceptScore W2045925057C71924100 @default.
• W2045925057 hasConceptScore W2045925057C84597430 @default.
• W2045925057 hasConceptScore W2045925057C86803240 @default.
• W2045925057 hasConceptScore W2045925057C99454951 @default.
• W2045925057 hasIssue "3" @default.
• W2045925057 hasLocation W20459250571 @default.
• W2045925057 hasLocation W20459250572 @default.
• W2045925057 hasOpenAccess W2045925057 @default.
• W2045925057 hasPrimaryLocation W20459250571 @default.
• W2045925057 hasRelatedWork W2003356174 @default.
• W2045925057 hasRelatedWork W2021956554 @default.
• W2045925057 hasRelatedWork W2033340178 @default.
• W2045925057 hasRelatedWork W2082571116 @default.
• W2045925057 hasRelatedWork W2124587417 @default.
• W2045925057 hasRelatedWork W2152531135 @default.
• W2045925057 hasRelatedWork W2589043292 @default.
• W2045925057 hasRelatedWork W2953466646 @default.
• W2045925057 hasRelatedWork W4281675959 @default.
• W2045925057 hasRelatedWork W2936812654 @default.
• W2045925057 hasVolume "2" @default.
• W2045925057 isParatext "false" @default.
• W2045925057 isRetracted "false" @default.
• W2045925057 magId "2045925057" @default.

• next