FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045927280> ?p ?o ?g. }

• W2045927280 endingPage "2105" @default.
• W2045927280 startingPage "2094" @default.
• W2045927280 abstract "Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measurements and quantification of the transmural perfusion gradient (TPG) could be more sensitive and specific for the detection of coronary artery disease (CAD). The current study aimed to determine the impact of lesion severity as assessed by the fractional flow reserve (FFR) on subendocardial perfusion and the TPG using [(15)O]H2O positron emission tomography (PET) imaging in patients evaluated for CAD.Sixty-six patients with anginal chest pain were prospectively enrolled and underwent [(15)O]H2O myocardial perfusion PET imaging. Subsequently, invasive coronary angiography was performed and FFR obtained in all coronary arteries irrespective of the PET imaging results. Thirty (45%) patients were diagnosed with significant CAD (i.e. FFR ≤0.80), whereas on a per vessel analysis (n = 198), 53 (27%) displayed a positive FFR. Transmural hyperaemic MBF decreased significantly from 3.09 ± 1.16 to 1.67 ± 0.57 mL min(-1) g(-1) (P < 0.001) in non-ischaemic and ischaemic myocardium, respectively. The TPG decreased during hyperaemia when compared with baseline (1.20 ± 0.14 vs. 0.94 ± 0.17, P < 0.001), and was lower in arteries with a positive FFR (0.97 ± 0.16 vs. 0.88 ± 0.18, P < 0.01). A TPG threshold of 0.94 yielded an accuracy to detect CAD of 59%, which was inferior to transmural MBF with an optimal cutoff of 2.20 mL min(-1) g(-1) and an accuracy of 85% (P < 0.001). Diagnostic accuracy of subendocardial perfusion measurements was comparable with transmural MBF (83 vs. 85%, respectively, P = NS).Cardiac [(15)O]H2O PET imaging is able to distinguish subendocardial from subepicardial perfusion in the myocardium of normal dimensions. Hyperaemic TPG is significantly lower in ischaemic myocardium. This technique can potentially be employed to study subendocardial perfusion impairment in more detail. However, the diagnostic accuracy of subendocardial hyperaemic perfusion and TPG appears to be limited compared with quantitative transmural MBF, warranting further study." @default.
• W2045927280 created "2016-06-24" @default.
• W2045927280 creator A5010287896 @default.
• W2045927280 creator A5021543324 @default.
• W2045927280 creator A5022701632 @default.
• W2045927280 creator A5028993103 @default.
• W2045927280 creator A5042586482 @default.
• W2045927280 creator A5047398592 @default.
• W2045927280 creator A5053893959 @default.
• W2045927280 creator A5071375873 @default.
• W2045927280 creator A5086285920 @default.
• W2045927280 creator A5088103668 @default.
• W2045927280 date "2014-04-29" @default.
• W2045927280 modified "2023-10-14" @default.
• W2045927280 title "Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [15O]H2O PET study" @default.
• W2045927280 cites W1484080302 @default.
• W2045927280 cites W1507712203 @default.
• W2045927280 cites W1972513278 @default.
• W2045927280 cites W1981245471 @default.
• W2045927280 cites W1995857985 @default.
• W2045927280 cites W1996105184 @default.
• W2045927280 cites W1996668234 @default.
• W2045927280 cites W2017634998 @default.
• W2045927280 cites W2037040142 @default.
• W2045927280 cites W2038704156 @default.
• W2045927280 cites W2039471471 @default.
• W2045927280 cites W2046003362 @default.
• W2045927280 cites W2049730148 @default.
• W2045927280 cites W2053177860 @default.
• W2045927280 cites W2062311377 @default.
• W2045927280 cites W2072389284 @default.
• W2045927280 cites W2089627065 @default.
• W2045927280 cites W2096864230 @default.
• W2045927280 cites W2096917705 @default.
• W2045927280 cites W2132401137 @default.
• W2045927280 cites W2134343469 @default.
• W2045927280 cites W2135402723 @default.
• W2045927280 cites W2137366510 @default.
• W2045927280 cites W2141044985 @default.
• W2045927280 cites W2145387017 @default.
• W2045927280 cites W2145861270 @default.
• W2045927280 cites W2147315244 @default.
• W2045927280 cites W2150086052 @default.
• W2045927280 cites W2160140536 @default.
• W2045927280 cites W2165548906 @default.
• W2045927280 cites W2169793356 @default.
• W2045927280 cites W2169973865 @default.
• W2045927280 cites W2320707747 @default.
• W2045927280 cites W2328176404 @default.
• W2045927280 doi "https://doi.org/10.1093/eurheartj/ehu170" @default.
• W2045927280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24780500" @default.
• W2045927280 hasPublicationYear "2014" @default.
• W2045927280 type Work @default.
• W2045927280 sameAs 2045927280 @default.
• W2045927280 citedByCount "62" @default.
• W2045927280 countsByYear W20459272802014 @default.
• W2045927280 countsByYear W20459272802015 @default.
• W2045927280 countsByYear W20459272802016 @default.
• W2045927280 countsByYear W20459272802017 @default.
• W2045927280 countsByYear W20459272802018 @default.
• W2045927280 countsByYear W20459272802019 @default.
• W2045927280 countsByYear W20459272802020 @default.
• W2045927280 countsByYear W20459272802021 @default.
• W2045927280 countsByYear W20459272802023 @default.
• W2045927280 crossrefType "journal-article" @default.
• W2045927280 hasAuthorship W2045927280A5010287896 @default.
• W2045927280 hasAuthorship W2045927280A5021543324 @default.
• W2045927280 hasAuthorship W2045927280A5022701632 @default.
• W2045927280 hasAuthorship W2045927280A5028993103 @default.
• W2045927280 hasAuthorship W2045927280A5042586482 @default.
• W2045927280 hasAuthorship W2045927280A5047398592 @default.
• W2045927280 hasAuthorship W2045927280A5053893959 @default.
• W2045927280 hasAuthorship W2045927280A5071375873 @default.
• W2045927280 hasAuthorship W2045927280A5086285920 @default.
• W2045927280 hasAuthorship W2045927280A5088103668 @default.
• W2045927280 hasBestOaLocation W20459272801 @default.
• W2045927280 hasConcept C126322002 @default.
• W2045927280 hasConcept C126838900 @default.
• W2045927280 hasConcept C135691158 @default.
• W2045927280 hasConcept C146957229 @default.
• W2045927280 hasConcept C158846371 @default.
• W2045927280 hasConcept C164705383 @default.
• W2045927280 hasConcept C2775842073 @default.
• W2045927280 hasConcept C2776820930 @default.
• W2045927280 hasConcept C2777691872 @default.
• W2045927280 hasConcept C2777987666 @default.
• W2045927280 hasConcept C2778213512 @default.
• W2045927280 hasConcept C2778405248 @default.
• W2045927280 hasConcept C2778742706 @default.
• W2045927280 hasConcept C2989005 @default.
• W2045927280 hasConcept C3019004856 @default.
• W2045927280 hasConcept C500558357 @default.
• W2045927280 hasConcept C71924100 @default.
• W2045927280 hasConceptScore W2045927280C126322002 @default.
• W2045927280 hasConceptScore W2045927280C126838900 @default.
• W2045927280 hasConceptScore W2045927280C135691158 @default.
• W2045927280 hasConceptScore W2045927280C146957229 @default.
• W2045927280 hasConceptScore W2045927280C158846371 @default.

• next