Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045933963> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2045933963 endingPage "504" @default.
- W2045933963 startingPage "501" @default.
- W2045933963 abstract "The reduced febrile response in aged man has been noted since the beginning of clinical thermometry. Our previous research on aged rabbits and squirrel monkeys disclosed a similar reduced fever, presumably due to a decrease in central receptors for endogenous pyrogen. However, because central alpha-melanocyte stimulating hormone (MSH) appears to have a potent role in physiological control of fever, it may be that increased release of the peptide is responsible for the reduced febrile response in aged animals. To test this idea, antiserum specific to MSH was administered intracerebroventricularly to rabbits of known age. The antiserum given according to three schedules of treatment augmented fever caused by IV injections of interleukin-1 (IL-1) in young (less than 2 years) male and female rabbits. Aged female rabbits (3-5+ years) and females aged 2-3 years showed significant augmentation of fever only after pretreatment plus acute injection of antiserum. A single ICV injection of MSH (200 ng) reduced fever in all groups with the greatest antipyretic effect in the aged females. The results indicate that while aged rabbits have an increased antipyretic response to central MSH, binding of the endogenous peptide does not result in marked increases in fever in these animals. Thus, whereas a change in central MSH sensitivity may contribute to reduced fever in aged homeotherms, a reduction in central pyrogen receptors appears to be the most parsimonious explanation." @default.
- W2045933963 created "2016-06-24" @default.
- W2045933963 creator A5000271183 @default.
- W2045933963 creator A5032064798 @default.
- W2045933963 creator A5081851878 @default.
- W2045933963 date "1987-05-01" @default.
- W2045933963 modified "2023-09-25" @default.
- W2045933963 title "Is the endogenous antipyretic neuropeptide α-MSH responsible for reduced fever in aged rabbits?" @default.
- W2045933963 cites W1562104550 @default.
- W2045933963 cites W1972232819 @default.
- W2045933963 cites W1973928770 @default.
- W2045933963 cites W1978375432 @default.
- W2045933963 cites W1981138025 @default.
- W2045933963 cites W2004256091 @default.
- W2045933963 cites W2009533976 @default.
- W2045933963 cites W2014248001 @default.
- W2045933963 cites W2030000344 @default.
- W2045933963 cites W2030096042 @default.
- W2045933963 cites W2032739021 @default.
- W2045933963 cites W2035799661 @default.
- W2045933963 cites W2043781778 @default.
- W2045933963 cites W2044871573 @default.
- W2045933963 cites W2050071961 @default.
- W2045933963 cites W2050874237 @default.
- W2045933963 cites W2056465213 @default.
- W2045933963 cites W2058362601 @default.
- W2045933963 cites W2074465342 @default.
- W2045933963 cites W2083063016 @default.
- W2045933963 cites W2094444031 @default.
- W2045933963 cites W2095648398 @default.
- W2045933963 cites W2416381026 @default.
- W2045933963 cites W581958311 @default.
- W2045933963 cites W852444359 @default.
- W2045933963 doi "https://doi.org/10.1016/0196-9781(87)90016-7" @default.
- W2045933963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2821521" @default.
- W2045933963 hasPublicationYear "1987" @default.
- W2045933963 type Work @default.
- W2045933963 sameAs 2045933963 @default.
- W2045933963 citedByCount "13" @default.
- W2045933963 crossrefType "journal-article" @default.
- W2045933963 hasAuthorship W2045933963A5000271183 @default.
- W2045933963 hasAuthorship W2045933963A5032064798 @default.
- W2045933963 hasAuthorship W2045933963A5081851878 @default.
- W2045933963 hasConcept C118303440 @default.
- W2045933963 hasConcept C126322002 @default.
- W2045933963 hasConcept C134018914 @default.
- W2045933963 hasConcept C147483822 @default.
- W2045933963 hasConcept C16613235 @default.
- W2045933963 hasConcept C170493617 @default.
- W2045933963 hasConcept C203014093 @default.
- W2045933963 hasConcept C2779252780 @default.
- W2045933963 hasConcept C2780820201 @default.
- W2045933963 hasConcept C56191518 @default.
- W2045933963 hasConcept C71924100 @default.
- W2045933963 hasConcept C86803240 @default.
- W2045933963 hasConcept C91523082 @default.
- W2045933963 hasConcept C98274493 @default.
- W2045933963 hasConceptScore W2045933963C118303440 @default.
- W2045933963 hasConceptScore W2045933963C126322002 @default.
- W2045933963 hasConceptScore W2045933963C134018914 @default.
- W2045933963 hasConceptScore W2045933963C147483822 @default.
- W2045933963 hasConceptScore W2045933963C16613235 @default.
- W2045933963 hasConceptScore W2045933963C170493617 @default.
- W2045933963 hasConceptScore W2045933963C203014093 @default.
- W2045933963 hasConceptScore W2045933963C2779252780 @default.
- W2045933963 hasConceptScore W2045933963C2780820201 @default.
- W2045933963 hasConceptScore W2045933963C56191518 @default.
- W2045933963 hasConceptScore W2045933963C71924100 @default.
- W2045933963 hasConceptScore W2045933963C86803240 @default.
- W2045933963 hasConceptScore W2045933963C91523082 @default.
- W2045933963 hasConceptScore W2045933963C98274493 @default.
- W2045933963 hasIssue "3" @default.
- W2045933963 hasLocation W20459339631 @default.
- W2045933963 hasLocation W20459339632 @default.
- W2045933963 hasOpenAccess W2045933963 @default.
- W2045933963 hasPrimaryLocation W20459339631 @default.
- W2045933963 hasRelatedWork W1976459836 @default.
- W2045933963 hasRelatedWork W1991350882 @default.
- W2045933963 hasRelatedWork W2007585091 @default.
- W2045933963 hasRelatedWork W2047252009 @default.
- W2045933963 hasRelatedWork W2048858255 @default.
- W2045933963 hasRelatedWork W2056057726 @default.
- W2045933963 hasRelatedWork W2079379846 @default.
- W2045933963 hasRelatedWork W2090420969 @default.
- W2045933963 hasRelatedWork W2114765598 @default.
- W2045933963 hasRelatedWork W2153915731 @default.
- W2045933963 hasVolume "8" @default.
- W2045933963 isParatext "false" @default.
- W2045933963 isRetracted "false" @default.
- W2045933963 magId "2045933963" @default.
- W2045933963 workType "article" @default.