FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045940028> ?p ?o ?g. }

• W2045940028 endingPage "539" @default.
• W2045940028 startingPage "535" @default.
• W2045940028 abstract "Alopecia areata is an acquired hair loss disorder resulting from an immunologically- mediated attack on hair follicles and autoimmunity may play a part in its pathogenesis. The non-synonymous C1858T substitution in the PTPN22 gene, which encodes lymphoid protein tyrosine phosphatase, has been shown to be associated with susceptibility to autoimmune disorders. In this study, the objective was to ascertain whether or not the disease-associated 1858T (W620) allele was associated with alopecia areata. For this, the allelic distribution of the PTPN22 C1858T alleles was determined in 196 English patients with alopecia areata and 507 healthy subjects in a case control study using a restriction fragment length polymorphism-polymerase chain reaction (PCR-RFLP) genotyping method. The results indicated that the frequency of the 1858T allele did not differ significantly between the alopecia areata patient group and the control cohort: of 392 alopecia areata alleles, 41 (10.5%) encoded the W620 variant compared to 86 of 1014 (8.5%) control alleles. However, in patients with severe disease, 25/168 (14.9%) alleles were 1858T and this frequency differed from that in the control group (P = 0.0127; OR, 95% CI = 1.89, 1.17 - 3.05). These results suggest that the non-synonymous C1858T substitution in the PTPN22 gene may have an influence on the severity of alopecia areata and provide further evidence for autoimmunity as an aetiological factor in this disorder." @default.
• W2045940028 created "2016-06-24" @default.
• W2045940028 creator A5026963044 @default.
• W2045940028 creator A5037334841 @default.
• W2045940028 creator A5041140181 @default.
• W2045940028 creator A5056902494 @default.
• W2045940028 creator A5068806445 @default.
• W2045940028 creator A5081606550 @default.
• W2045940028 creator A5082549110 @default.
• W2045940028 date "2006-07-01" @default.
• W2045940028 modified "2023-09-24" @default.
• W2045940028 title "The Non-Synonymous C1858T Substitution in the PTPN22 Gene is Associated with Susceptibility to the Severe Forms of Alopecia Areata" @default.
• W2045940028 cites W1501940489 @default.
• W2045940028 cites W1583317594 @default.
• W2045940028 cites W1968216911 @default.
• W2045940028 cites W1974722772 @default.
• W2045940028 cites W1979482663 @default.
• W2045940028 cites W1985634242 @default.
• W2045940028 cites W1987677365 @default.
• W2045940028 cites W1994402720 @default.
• W2045940028 cites W2003128108 @default.
• W2045940028 cites W2005881579 @default.
• W2045940028 cites W2008649874 @default.
• W2045940028 cites W2017689331 @default.
• W2045940028 cites W2019555374 @default.
• W2045940028 cites W2035064373 @default.
• W2045940028 cites W2054038622 @default.
• W2045940028 cites W2079078071 @default.
• W2045940028 cites W2082117580 @default.
• W2045940028 cites W2135167801 @default.
• W2045940028 cites W2140707353 @default.
• W2045940028 cites W2142155452 @default.
• W2045940028 cites W2158175056 @default.
• W2045940028 cites W2163735374 @default.
• W2045940028 cites W317592431 @default.
• W2045940028 cites W4252921543 @default.
• W2045940028 doi "https://doi.org/10.1016/j.humimm.2006.04.006" @default.
• W2045940028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16829308" @default.
• W2045940028 hasPublicationYear "2006" @default.
• W2045940028 type Work @default.
• W2045940028 sameAs 2045940028 @default.
• W2045940028 citedByCount "39" @default.
• W2045940028 countsByYear W20459400282012 @default.
• W2045940028 countsByYear W20459400282013 @default.
• W2045940028 countsByYear W20459400282014 @default.
• W2045940028 countsByYear W20459400282015 @default.
• W2045940028 countsByYear W20459400282016 @default.
• W2045940028 countsByYear W20459400282017 @default.
• W2045940028 countsByYear W20459400282018 @default.
• W2045940028 countsByYear W20459400282019 @default.
• W2045940028 countsByYear W20459400282020 @default.
• W2045940028 countsByYear W20459400282021 @default.
• W2045940028 countsByYear W20459400282022 @default.
• W2045940028 crossrefType "journal-article" @default.
• W2045940028 hasAuthorship W2045940028A5026963044 @default.
• W2045940028 hasAuthorship W2045940028A5037334841 @default.
• W2045940028 hasAuthorship W2045940028A5041140181 @default.
• W2045940028 hasAuthorship W2045940028A5056902494 @default.
• W2045940028 hasAuthorship W2045940028A5068806445 @default.
• W2045940028 hasAuthorship W2045940028A5081606550 @default.
• W2045940028 hasAuthorship W2045940028A5082549110 @default.
• W2045940028 hasConcept C104317684 @default.
• W2045940028 hasConcept C135763542 @default.
• W2045940028 hasConcept C153209595 @default.
• W2045940028 hasConcept C159654299 @default.
• W2045940028 hasConcept C180754005 @default.
• W2045940028 hasConcept C203014093 @default.
• W2045940028 hasConcept C2777524370 @default.
• W2045940028 hasConcept C2779356809 @default.
• W2045940028 hasConcept C2780130043 @default.
• W2045940028 hasConcept C2780942790 @default.
• W2045940028 hasConcept C31467283 @default.
• W2045940028 hasConcept C37463918 @default.
• W2045940028 hasConcept C54355233 @default.
• W2045940028 hasConcept C71924100 @default.
• W2045940028 hasConcept C86803240 @default.
• W2045940028 hasConceptScore W2045940028C104317684 @default.
• W2045940028 hasConceptScore W2045940028C135763542 @default.
• W2045940028 hasConceptScore W2045940028C153209595 @default.
• W2045940028 hasConceptScore W2045940028C159654299 @default.
• W2045940028 hasConceptScore W2045940028C180754005 @default.
• W2045940028 hasConceptScore W2045940028C203014093 @default.
• W2045940028 hasConceptScore W2045940028C2777524370 @default.
• W2045940028 hasConceptScore W2045940028C2779356809 @default.
• W2045940028 hasConceptScore W2045940028C2780130043 @default.
• W2045940028 hasConceptScore W2045940028C2780942790 @default.
• W2045940028 hasConceptScore W2045940028C31467283 @default.
• W2045940028 hasConceptScore W2045940028C37463918 @default.
• W2045940028 hasConceptScore W2045940028C54355233 @default.
• W2045940028 hasConceptScore W2045940028C71924100 @default.
• W2045940028 hasConceptScore W2045940028C86803240 @default.
• W2045940028 hasIssue "7" @default.
• W2045940028 hasLocation W20459400281 @default.
• W2045940028 hasLocation W20459400282 @default.
• W2045940028 hasOpenAccess W2045940028 @default.
• W2045940028 hasPrimaryLocation W20459400281 @default.
• W2045940028 hasRelatedWork W1965247597 @default.
• W2045940028 hasRelatedWork W1969825491 @default.

• next