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• W2045947182 abstract "Nanos is an RNA-binding protein that is involved in the development and maintenance of germ cells. In combination with Pumilio, Nanos binds to the 3' untranslated region of a messenger RNA and represses its translation. Nanos has two conserved Cys-Cys-His-Cys zinc-finger motifs that are indispensable for its function. In this study, we have determined the crystal structure of the zinc-finger domain of zebrafish Nanos, for the first time revealing that Nanos adopts a novel zinc-finger structure. In addition, Nanos has a conserved basic surface that is directly involved in RNA binding. Our results provide the structural basis for further studies to clarify Nanos function." @default.
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• W2045947182 date "2010-10-15" @default.
• W2045947182 modified "2023-10-17" @default.
• W2045947182 title "Crystal structure of zinc‐finger domain of Nanos and its functional implications" @default.
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• W2045947182 doi "https://doi.org/10.1038/embor.2010.155" @default.
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