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- W2045947786 abstract "The distinguishing feature of the eosinophil under the light microscope is the dense eosinophilic granulation which may completely fill the cytoplasm. When viewed under the electron microscope, the eosinophil granule, as shown in Fig. 1, is seen as a membrane-bounded cytoplasmic organelle with a distinctive internal structure.” In most cases, the eosinophil granule has an electron-dense core and a less dense matrix. The core occurs in a variety of sizes and shapes. When eosinophils are stained for peroxidase activity, there is a reversal of the usual pattern of granule staining; in this case the matrix is electrondense and the core is less dense. This finding is consistent with the view that the eosinophil peroxidase is localized in the matrix because the electron-dense product frclm the peroxidase reaction deposits in the granule matrix. As seen in Fig. 2, when the core of the granule is examined under high magnification, there appears to be a periodicity in both the longitudinal and cross-sectional dimensions.4 Because of this regular structure, the core of the eosinophil granule has been termed a crystalloid and some authors have suggested that the Charcot-Leyden crystal (CLC) is derived from the core.5’ ’ In addition to the typical eosinophil granules described above, another type of granule has recently been described in human eosinophils.’ This granule is membra.ne-bounded, is smaller in diameter than the crystalloid-containing granules, and is enriched" @default.
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- W2045947786 date "1977-07-01" @default.
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- W2045947786 title "The eosinophil: New aspects of structure and function" @default.
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- W2045947786 doi "https://doi.org/10.1016/0091-6749(77)90086-0" @default.
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