FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045949922> ?p ?o ?g. }

• W2045949922 endingPage "9" @default.
• W2045949922 startingPage "1" @default.
• W2045949922 abstract "Studies indicate the dramatic reduction of shear stress (SS) within the rapamycin eluting stent (RES) segment of coronary arteries. It remains unclear about the role of rapamycin in endothelialization of stented arteries where SS becomes low. Since mTOR (mammalian target of rapamycin) pathway is involved in the antioxidative sestrins expression, we hypothesized that rapamycin attenuated low SS (LSS) induced endothelial dysfunction through mTOR and sestrin1 associated redox regulation.To mimic the effect of LSS on the stented arteries, a parallel plate flow chamber was used to observe the interplay of LSS and rapamycin on endothelial cells (ECs). The results showed LSS significantly induced EC apoptosis which was mitigated by pretreatment of rapamycin. Rapamycin attenuated LSS induced reactive oxygen species (ROS) and reactive nitrogen species (RNS) production via prohibition of sestrin1 downregulation. Activities of mTORC1 and mTORC2 were detected contradictorily modulated by LSS. Inhibition of rictor expression by target small interfering RNA (siRNA) transfection prohibited sestrin1 downregulation induced by LSS, but inhibition of raptor did not.Rapamycin may prohibit sestrin1 downregulation through targeting mTORC2 in appeasing LSS induced EC oxidative apoptosis. Our results provide the in vitro evidence to explain the pathophysiology of RES stented arteries." @default.
• W2045949922 created "2016-06-24" @default.
• W2045949922 creator A5016722530 @default.
• W2045949922 creator A5018122772 @default.
• W2045949922 creator A5030931393 @default.
• W2045949922 creator A5034727289 @default.
• W2045949922 creator A5040352591 @default.
• W2045949922 creator A5049799952 @default.
• W2045949922 creator A5083581319 @default.
• W2045949922 date "2014-01-01" @default.
• W2045949922 modified "2023-10-05" @default.
• W2045949922 title "Rapamycin Attenuates Endothelial Apoptosis Induced by Low Shear Stress via mTOR and Sestrin1 Related Redox Regulation" @default.
• W2045949922 cites W1256715555 @default.
• W2045949922 cites W13897408 @default.
• W2045949922 cites W1507948369 @default.
• W2045949922 cites W1527614413 @default.
• W2045949922 cites W1554888293 @default.
• W2045949922 cites W1832237662 @default.
• W2045949922 cites W1891170558 @default.
• W2045949922 cites W1963722732 @default.
• W2045949922 cites W1965141994 @default.
• W2045949922 cites W196677194 @default.
• W2045949922 cites W1972618720 @default.
• W2045949922 cites W1974942240 @default.
• W2045949922 cites W1975529354 @default.
• W2045949922 cites W1978573346 @default.
• W2045949922 cites W1988463172 @default.
• W2045949922 cites W1996856965 @default.
• W2045949922 cites W1997723138 @default.
• W2045949922 cites W1997766296 @default.
• W2045949922 cites W1999671588 @default.
• W2045949922 cites W2006343812 @default.
• W2045949922 cites W2014320780 @default.
• W2045949922 cites W2026044755 @default.
• W2045949922 cites W2029044425 @default.
• W2045949922 cites W2044441834 @default.
• W2045949922 cites W2046654320 @default.
• W2045949922 cites W2049812539 @default.
• W2045949922 cites W2053724304 @default.
• W2045949922 cites W2057892556 @default.
• W2045949922 cites W2067976787 @default.
• W2045949922 cites W2069258667 @default.
• W2045949922 cites W2102725965 @default.
• W2045949922 cites W2103766009 @default.
• W2045949922 cites W2104394381 @default.
• W2045949922 cites W2108355760 @default.
• W2045949922 cites W2119239003 @default.
• W2045949922 cites W2122338853 @default.
• W2045949922 cites W2125674758 @default.
• W2045949922 cites W2126550955 @default.
• W2045949922 cites W2143139829 @default.
• W2045949922 cites W2167795228 @default.
• W2045949922 cites W2517054293 @default.
• W2045949922 doi "https://doi.org/10.1155/2014/769608" @default.
• W2045949922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3920857" @default.
• W2045949922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24587596" @default.
• W2045949922 hasPublicationYear "2014" @default.
• W2045949922 type Work @default.
• W2045949922 sameAs 2045949922 @default.
• W2045949922 citedByCount "29" @default.
• W2045949922 countsByYear W20459499222015 @default.
• W2045949922 countsByYear W20459499222016 @default.
• W2045949922 countsByYear W20459499222017 @default.
• W2045949922 countsByYear W20459499222018 @default.
• W2045949922 countsByYear W20459499222019 @default.
• W2045949922 countsByYear W20459499222020 @default.
• W2045949922 countsByYear W20459499222021 @default.
• W2045949922 countsByYear W20459499222022 @default.
• W2045949922 countsByYear W20459499222023 @default.
• W2045949922 crossrefType "journal-article" @default.
• W2045949922 hasAuthorship W2045949922A5016722530 @default.
• W2045949922 hasAuthorship W2045949922A5018122772 @default.
• W2045949922 hasAuthorship W2045949922A5030931393 @default.
• W2045949922 hasAuthorship W2045949922A5034727289 @default.
• W2045949922 hasAuthorship W2045949922A5040352591 @default.
• W2045949922 hasAuthorship W2045949922A5049799952 @default.
• W2045949922 hasAuthorship W2045949922A5083581319 @default.
• W2045949922 hasBestOaLocation W20459499221 @default.
• W2045949922 hasConcept C104317684 @default.
• W2045949922 hasConcept C107846503 @default.
• W2045949922 hasConcept C127561419 @default.
• W2045949922 hasConcept C185592680 @default.
• W2045949922 hasConcept C190283241 @default.
• W2045949922 hasConcept C22615655 @default.
• W2045949922 hasConcept C2776151105 @default.
• W2045949922 hasConcept C48349386 @default.
• W2045949922 hasConcept C54009773 @default.
• W2045949922 hasConcept C55493867 @default.
• W2045949922 hasConcept C86554907 @default.
• W2045949922 hasConcept C86803240 @default.
• W2045949922 hasConcept C95444343 @default.
• W2045949922 hasConcept C98490376 @default.
• W2045949922 hasConceptScore W2045949922C104317684 @default.
• W2045949922 hasConceptScore W2045949922C107846503 @default.
• W2045949922 hasConceptScore W2045949922C127561419 @default.
• W2045949922 hasConceptScore W2045949922C185592680 @default.
• W2045949922 hasConceptScore W2045949922C190283241 @default.
• W2045949922 hasConceptScore W2045949922C22615655 @default.

• next