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- W2045949991 abstract "Expoxyeicosatrienoic acids (EETs) are arachidonic acid metabolites of CYP450 epoxygenases which are rapidly metabolised by the ubiquitously expressed enzyme soluble epoxide hydrolase (sEH) to their respective diols the dihydroxyeicosatrienoic acids (DHET)1. EETs exert numerous beneficial actions on the cardiovascular system, including vasodilation, cardio-protection and anti-inflammatory actions1. The biological effects of EETs and limited by their rapid metabolism and excretion, hence the use of sEH inhibitors has yielded promising results in cardiac myocyte assays and animal models of cardiac remodelling associated with hypertension2,3, reducing hypertrophy and fibrosis. A recent study using a model of myocardial ischaemia/reperfusion injury showed beneficial cardiac remodelling effects with sEH inhibition at 3 weeks after injury4. These studies suggest that the beneficial effects already observed with this class of compounds warrant further investigation utilising a chronic and more dramatic model of cardiac dysfunction and remodelling. In this study we investigated sEH inhibition in a permanently ligated coronary artery (LAD) model of myocardial infarction. Figure 6: Inflammatory cells: GSK reduced interstitial macrophage infiltration Sham MI + Vehicle MI + GSK Results" @default.
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- W2045949991 date "2010-01-01" @default.
- W2045949991 modified "2023-09-29" @default.
- W2045949991 title "Soluble Epoxide Hydrolase Inhibition Attenuates Cardiac Remodelling Post-myocardial Infarction" @default.
- W2045949991 doi "https://doi.org/10.1016/j.hlc.2010.06.856" @default.
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