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• W2045951692 abstract "Data from epidemiologic and genome-wide association studies support the role of inherited predisposition in lung carcinogenesis, even after adjustment for age, sex, and smoking habits.1,2 Because lung cancer is most often diagnosed at advanced stages when there are no curative therapies, there is a critical need to identify patients who are at inherited risk. Identification of such patients is especially important because screening tests have been shown to reduce death from lung cancer in high-risk individuals.3 Germline epidermal growth factor receptor (EGFR) T790M is a rare mutation, which is associated with familial lung cancer; only 10 cases have thus far been reported, usually in association with concurrent somatic gain-of-function EGFR mutations.4–9 We describe 2 contrasting presentations of germline EGFR T790M mutation, including a previously undescribed patient with a concurrent KRAS mutation, and discuss the potential pathogenesis of lung cancer in these patients." @default.
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• W2045951692 date "2013-07-01" @default.
• W2045951692 modified "2023-10-18" @default.
• W2045951692 title "Concurrent Molecular Alterations in Tumors With Germ Line Epidermal Growth Factor Receptor T790M Mutations" @default.
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• W2045951692 doi "https://doi.org/10.1016/j.cllc.2013.01.005" @default.
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