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• W2045951927 endingPage "6573" @default.
• W2045951927 startingPage "6559" @default.
• W2045951927 abstract "ABSTRACT We have previously identified a process in the yeast Saccharomyces cerevisiae that results in the contraction of elongated telomeres to wild-type length within a few generations. We have termed this process telomeric rapid deletion (TRD). In this study, we use a combination of physical and genetic assays to investigate the mechanism of TRD. First, to distinguish among several recombinational and nucleolytic pathways, we developed a novel physical assay in which Hae III restriction sites are positioned within the telomeric tract. Specific telomeres were subsequently tested for Hae III site movement between telomeres and for Hae III site retention during TRD. Second, genetic analyses have demonstrated that mutations in RAD50 and MRE11 inhibit TRD. TRD, however, is independent of the Rap1p C-terminal domain, a central regulator of telomere size control. Our results provide evidence that TRD is an intrachromatid deletion process in which sequences near the extreme terminus invade end-distal sequences and excise the intervening sequences. We propose that the Mre11p-Rad50p-Xrs2p complex prepares the invading telomeric overhang for strand invasion, possibly through end processing or through alterations in chromatin structure." @default.
• W2045951927 created "2016-06-24" @default.
• W2045951927 creator A5000659281 @default.
• W2045951927 creator A5012132645 @default.
• W2045951927 creator A5030646897 @default.
• W2045951927 date "2001-10-01" @default.
• W2045951927 modified "2023-09-26" @default.
• W2045951927 title "Intrachromatid Excision of Telomeric DNA as a Mechanism for Telomere Size Control in <i>Saccharomyces cerevisiae</i>" @default.
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• W2045951927 doi "https://doi.org/10.1128/mcb.21.19.6559-6573.2001" @default.
• W2045951927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/99802" @default.
• W2045951927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11533244" @default.
• W2045951927 hasPublicationYear "2001" @default.
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• W2045951927 hasAuthorship W2045951927A5000659281 @default.
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