Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045955260> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2045955260 endingPage "228" @default.
- W2045955260 startingPage "224" @default.
- W2045955260 abstract "To investigate the mechanisms of abnormal calcium metabolism, such as hypocalcemia, decreased intestinal calcium absorption and hypercalciuria in spontaneously hypertensive rats (SHR), we have measured the plasma concentration of calcitriol and its synthesis in 5-, 8-, 12-, 16-, and 20-week-old normotensive Wistar Kyoto rats (WKY) and SHR. Metabolic clearance rate (MCR) and production rate (PR) of calcitriol were measured by the constant isotope infusion method. Plasma concentration of calcitriol and PR of calcitriol were decreased in SHR after 12 weeks of age. MCR of calcitriol, however, was not different between WKY and SHR in any age group. Therefore, the decreased synthesis of calcitriol accounts for the lower plasma level of calcitriol in SHR after 12 weeks of age. Metabolic acidosis or decreased renal function could not account for the decreased synthesis of calcitriol, since the blood pH and pCO2 and creatinine clearance were similar between WKY and SHR at times when the calcitriol synthesis was reduced in SHR. Plasma concentration of ionized calcium was also lower in SHR after 12 weeks of age. Plasma concentration of calcitonin was significantly higher in 16-week-old SHR (41.6 +/- 1.5 pg/ml) than in age-matched WKY (30.5 +/- 1.7, P less than 0.001). The values, however, were not different between 8- and 12-week-old WKY and SHR. We believe that the decreased synthesis of calcitriol could be the pathogenetic factor for the development of abnormal calcium metabolism in SHR. Age of animals should be considered when studying the calcium metabolism in SHR." @default.
- W2045955260 created "2016-06-24" @default.
- W2045955260 creator A5020734383 @default.
- W2045955260 creator A5055765396 @default.
- W2045955260 creator A5076312165 @default.
- W2045955260 date "1988-08-01" @default.
- W2045955260 modified "2023-09-29" @default.
- W2045955260 title "Calcitriol synthesis is decreased in spontaneously hypertensive rats" @default.
- W2045955260 cites W1965597093 @default.
- W2045955260 cites W1973597536 @default.
- W2045955260 cites W1993777031 @default.
- W2045955260 cites W2062395637 @default.
- W2045955260 cites W2064871248 @default.
- W2045955260 cites W2068831921 @default.
- W2045955260 cites W2070985645 @default.
- W2045955260 cites W2076871833 @default.
- W2045955260 cites W2078311756 @default.
- W2045955260 cites W2091829139 @default.
- W2045955260 cites W2103347470 @default.
- W2045955260 cites W2117498323 @default.
- W2045955260 cites W2126470866 @default.
- W2045955260 cites W2167999248 @default.
- W2045955260 cites W66099245 @default.
- W2045955260 doi "https://doi.org/10.1038/ki.1988.168" @default.
- W2045955260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3184598" @default.
- W2045955260 hasPublicationYear "1988" @default.
- W2045955260 type Work @default.
- W2045955260 sameAs 2045955260 @default.
- W2045955260 citedByCount "6" @default.
- W2045955260 countsByYear W20459552602014 @default.
- W2045955260 crossrefType "journal-article" @default.
- W2045955260 hasAuthorship W2045955260A5020734383 @default.
- W2045955260 hasAuthorship W2045955260A5055765396 @default.
- W2045955260 hasAuthorship W2045955260A5076312165 @default.
- W2045955260 hasBestOaLocation W20459552601 @default.
- W2045955260 hasConcept C126322002 @default.
- W2045955260 hasConcept C134018914 @default.
- W2045955260 hasConcept C159641895 @default.
- W2045955260 hasConcept C185592680 @default.
- W2045955260 hasConcept C2776079296 @default.
- W2045955260 hasConcept C2777724520 @default.
- W2045955260 hasConcept C2779627488 @default.
- W2045955260 hasConcept C519063684 @default.
- W2045955260 hasConcept C71924100 @default.
- W2045955260 hasConcept C87975464 @default.
- W2045955260 hasConceptScore W2045955260C126322002 @default.
- W2045955260 hasConceptScore W2045955260C134018914 @default.
- W2045955260 hasConceptScore W2045955260C159641895 @default.
- W2045955260 hasConceptScore W2045955260C185592680 @default.
- W2045955260 hasConceptScore W2045955260C2776079296 @default.
- W2045955260 hasConceptScore W2045955260C2777724520 @default.
- W2045955260 hasConceptScore W2045955260C2779627488 @default.
- W2045955260 hasConceptScore W2045955260C519063684 @default.
- W2045955260 hasConceptScore W2045955260C71924100 @default.
- W2045955260 hasConceptScore W2045955260C87975464 @default.
- W2045955260 hasIssue "2" @default.
- W2045955260 hasLocation W20459552601 @default.
- W2045955260 hasLocation W20459552602 @default.
- W2045955260 hasOpenAccess W2045955260 @default.
- W2045955260 hasPrimaryLocation W20459552601 @default.
- W2045955260 hasRelatedWork W2005296604 @default.
- W2045955260 hasRelatedWork W2016519769 @default.
- W2045955260 hasRelatedWork W2020570421 @default.
- W2045955260 hasRelatedWork W2048007834 @default.
- W2045955260 hasRelatedWork W2055353584 @default.
- W2045955260 hasRelatedWork W2063310434 @default.
- W2045955260 hasRelatedWork W2116754916 @default.
- W2045955260 hasRelatedWork W2151200102 @default.
- W2045955260 hasRelatedWork W2154583434 @default.
- W2045955260 hasRelatedWork W2050330784 @default.
- W2045955260 hasVolume "34" @default.
- W2045955260 isParatext "false" @default.
- W2045955260 isRetracted "false" @default.
- W2045955260 magId "2045955260" @default.
- W2045955260 workType "article" @default.