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- W2045956714 abstract "Premises for the subspecialty of hepatoimmunology include the recognition that the liver is a lymphoid organ with unique immunological properties. These properties ensure efficient innate defence against intestinal microbes and toxins, confer a particular capacity for induction of tolerance, and provide for apoptotic disposal of redundant lymphocytes. Pathological responses within the liver are elicited when: (i) hepatotropic viruses (hepatitis virus B and C) escape immune elimination and reside in hepatocytes; (ii) the liver becomes the site of autoimmune responses directed against either hepatocytes (autoimmune hepatitis) or biliary ductules (primary biliary cirrhosis); or (iii) the liver in the course of disposal of drugs generates neoantigens that provoke adverse allergic responses. Recent advances in the understanding of the immunopathogenesis of these entities are reviewed." @default.
- W2045956714 created "2016-06-24" @default.
- W2045956714 creator A5073399902 @default.
- W2045956714 date "2002-02-01" @default.
- W2045956714 modified "2023-09-29" @default.
- W2045956714 title "Hepatoimmunology: A perspective" @default.
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- W2045956714 doi "https://doi.org/10.1046/j.1440-1711.2002.01063.x" @default.
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