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- W2045956937 abstract "Nuclear reprogramming directed by the ooplasm is essential for producing cloned animals by somatic cell nuclear transfer (SCNT). One component of the reprogramming process is the removal of somatic histone H1 variants followed by replacement by the oocyte-specific form, H1FOO [ 1 Gao S. et al. Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice. Dev. Biol. 2004; 266: 62-75 Crossref PubMed Scopus (116) Google Scholar ]. Despite occurrence of this transition in 100% of SCNT constructs, cloned embryo development remains poor and cloned embryos express numerous somatic cell characteristics [ 2 Gao S. et al. Somatic cell-like features of cloned mouse embryos prepared with cultured myoblast nuclei. Biol. Reprod. 2003; 69: 48-56 Crossref PubMed Scopus (122) Google Scholar ], indicating that reprogramming is slow or incomplete." @default.
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- W2045956937 date "2005-02-01" @default.
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- W2045956937 title "Protease inhibitor MG132 in cloning: no end to the nightmare" @default.
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