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- W2045958488 abstract "The mapping of complex traits such as asthma and atopy is one of the most important and central areas of human genetics. This article will present an overview of the current status of genetic studies of asthma and atopy using genome screens and association studies that have occurred in the literature since January 2003.Many regions of the genome have been found to have linkage with the phenotypes of asthma and atopy. Over 70 variants in candidate genes have been reported to be associated with these phenotypes. The main regions these variants have been found are on chromosomes 2q, 5q, 6p, 11q, 12q, 16q and 17q. Five potential asthma susceptibility genes or complexes have been identified using a positional approach. These are ADAM33, DPP10, PHF11 and SETDB2, GPRA and SPINK5. It is evident that environmental factors will influence the expression of genes and the ultimate clinical phenotype of asthma and atopy.The development of asthma and atopy involves many genes and environmental factors. An understanding of their genetic basis has great implications for their management." @default.
- W2045958488 created "2016-06-24" @default.
- W2045958488 creator A5032054959 @default.
- W2045958488 date "2005-04-01" @default.
- W2045958488 modified "2023-10-15" @default.
- W2045958488 title "The role of genetics in the development of asthma and atopy" @default.
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- W2045958488 doi "https://doi.org/10.1097/01.all.0000162306.12728.c2" @default.
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