Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045960055> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2045960055 endingPage "1132" @default.
- W2045960055 startingPage "1126" @default.
- W2045960055 abstract "Endothelium-dependent relaxation of the aorta was assessed in JCR:LA-corpulent rats, which are hyperphagous, hyperlipidemic, hyperinsulinemic, and obese and spontaneously develop atherosclerotic disease and myocardial lesions. The findings in corpulent rats (6 months of age) were compared with those in age-and sex-matched lean rats. Aortic rings were prepared and mounted in Krebs-Henseleit buffer in a conventional organ bath. The tissue was contracted with norepinephrine (10(-6) mol/L), and relaxation was induced using acetylcholine, the calcium ionophore A23187, or bradykinin. The maximum relaxation to acetylcholine was impaired in corpulent male rats compared with lean rats, whereas relaxation in response to the calcium ionophore was similar in the corpulent and lean animals. Aortic rings from corpulent and lean female rats showed no differences in response to acetylcholine or to the calcium ionophore. Removal of endothelium resulted in the loss of relaxant response to acetylcholine and the calcium ionophore. The relaxant responses to sodium nitrite were not significantly different in the corpulent and lean male rats when deendothelialized tissues were examined, but the sensitivity to sodium nitrite was significantly lower in rings from corpulent male rats with intact endothelium. There were no differences in the response to bradykinin between corpulent and lean rats. These findings suggest that there is a specific impairment of endothelium-dependent relaxation in the corpulent male rat that is limited to that mediated by muscarinic receptors. The possibility that endothelium-derived contractile agents are secreted in the vessels of corpulent male rats cannot be excluded." @default.
- W2045960055 created "2016-06-24" @default.
- W2045960055 creator A5037948091 @default.
- W2045960055 creator A5040453423 @default.
- W2045960055 creator A5073156383 @default.
- W2045960055 creator A5088647970 @default.
- W2045960055 date "1994-06-01" @default.
- W2045960055 modified "2023-09-27" @default.
- W2045960055 title "Defective endothelium-dependent relaxation in the JCR:LA-corpulent rat." @default.
- W2045960055 cites W1965285288 @default.
- W2045960055 cites W1971398565 @default.
- W2045960055 cites W1975567521 @default.
- W2045960055 cites W1982065972 @default.
- W2045960055 cites W1992718978 @default.
- W2045960055 cites W1997370350 @default.
- W2045960055 cites W2001620934 @default.
- W2045960055 cites W2002648574 @default.
- W2045960055 cites W2013742432 @default.
- W2045960055 cites W2024385957 @default.
- W2045960055 cites W2024434488 @default.
- W2045960055 cites W2025445144 @default.
- W2045960055 cites W2027401509 @default.
- W2045960055 cites W2032278674 @default.
- W2045960055 cites W2033525828 @default.
- W2045960055 cites W2081652758 @default.
- W2045960055 cites W2098108865 @default.
- W2045960055 cites W2106595177 @default.
- W2045960055 cites W2145654319 @default.
- W2045960055 cites W2149893875 @default.
- W2045960055 cites W2162804111 @default.
- W2045960055 cites W2332979471 @default.
- W2045960055 cites W2345404920 @default.
- W2045960055 cites W2406750917 @default.
- W2045960055 doi "https://doi.org/10.1161/01.res.74.6.1126" @default.
- W2045960055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8187279" @default.
- W2045960055 hasPublicationYear "1994" @default.
- W2045960055 type Work @default.
- W2045960055 sameAs 2045960055 @default.
- W2045960055 citedByCount "31" @default.
- W2045960055 countsByYear W20459600552015 @default.
- W2045960055 countsByYear W20459600552017 @default.
- W2045960055 countsByYear W20459600552018 @default.
- W2045960055 countsByYear W20459600552020 @default.
- W2045960055 countsByYear W20459600552021 @default.
- W2045960055 countsByYear W20459600552022 @default.
- W2045960055 crossrefType "journal-article" @default.
- W2045960055 hasAuthorship W2045960055A5037948091 @default.
- W2045960055 hasAuthorship W2045960055A5040453423 @default.
- W2045960055 hasAuthorship W2045960055A5073156383 @default.
- W2045960055 hasAuthorship W2045960055A5088647970 @default.
- W2045960055 hasBestOaLocation W20459600551 @default.
- W2045960055 hasConcept C120770815 @default.
- W2045960055 hasConcept C126322002 @default.
- W2045960055 hasConcept C134018914 @default.
- W2045960055 hasConcept C170493617 @default.
- W2045960055 hasConcept C185592680 @default.
- W2045960055 hasConcept C2775910092 @default.
- W2045960055 hasConcept C2776992346 @default.
- W2045960055 hasConcept C2779014961 @default.
- W2045960055 hasConcept C2779591629 @default.
- W2045960055 hasConcept C519063684 @default.
- W2045960055 hasConcept C71924100 @default.
- W2045960055 hasConceptScore W2045960055C120770815 @default.
- W2045960055 hasConceptScore W2045960055C126322002 @default.
- W2045960055 hasConceptScore W2045960055C134018914 @default.
- W2045960055 hasConceptScore W2045960055C170493617 @default.
- W2045960055 hasConceptScore W2045960055C185592680 @default.
- W2045960055 hasConceptScore W2045960055C2775910092 @default.
- W2045960055 hasConceptScore W2045960055C2776992346 @default.
- W2045960055 hasConceptScore W2045960055C2779014961 @default.
- W2045960055 hasConceptScore W2045960055C2779591629 @default.
- W2045960055 hasConceptScore W2045960055C519063684 @default.
- W2045960055 hasConceptScore W2045960055C71924100 @default.
- W2045960055 hasIssue "6" @default.
- W2045960055 hasLocation W20459600551 @default.
- W2045960055 hasLocation W20459600552 @default.
- W2045960055 hasLocation W20459600553 @default.
- W2045960055 hasOpenAccess W2045960055 @default.
- W2045960055 hasPrimaryLocation W20459600551 @default.
- W2045960055 hasRelatedWork W1968517308 @default.
- W2045960055 hasRelatedWork W2019025724 @default.
- W2045960055 hasRelatedWork W2026082545 @default.
- W2045960055 hasRelatedWork W2072893770 @default.
- W2045960055 hasRelatedWork W2082935567 @default.
- W2045960055 hasRelatedWork W2084589401 @default.
- W2045960055 hasRelatedWork W2401763302 @default.
- W2045960055 hasRelatedWork W2472496493 @default.
- W2045960055 hasRelatedWork W3149708726 @default.
- W2045960055 hasRelatedWork W2412211087 @default.
- W2045960055 hasVolume "74" @default.
- W2045960055 isParatext "false" @default.
- W2045960055 isRetracted "false" @default.
- W2045960055 magId "2045960055" @default.
- W2045960055 workType "article" @default.