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- W2045960315 abstract "The azapeptide derivative 12 is obtained in a 7-step synthesis by coupling the components 5 and 11 in the last step. Whereas the azaamino acid residue in 5 is generated by a hydrazine/isocyanate addition, the other coupling steps are done using the carbodiimide/HOBt method. Compound 12 could be shown to inhibit the enzyme renin. Synthese eines Renin-Inhibitors vom Azapeptid-Typ Das Azapeptid-Derivat 12 wird in einer 7-Stufen-Synthese durch Kupplung der Komponenten 5 und 11 im letzten Schritt erhalten. Während der Azaaminosäure-Rest in 5 durch eine Hydrazin/Isocyanat-Addition aufgebaut wird, werden die übrigen Kupplungen nach der Carbodiimid/HOBt-Methode durchgeführt. Verbindung 12 erwies sich als Inhibitor des Enzyms Renin." @default.
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- W2045960315 date "1989-11-13" @default.
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- W2045960315 title "Synthesis of a Renin Inhibitor of the Azapeptide Type" @default.
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- W2045960315 doi "https://doi.org/10.1002/jlac.198919890273" @default.
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