FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045962246> ?p ?o ?g. }

• W2045962246 endingPage "190" @default.
• W2045962246 startingPage "183" @default.
• W2045962246 abstract "The mechanism of bone resorption induced by interleukin 1 (IL-1) was examined in mice using three different in vitro assay systems: a fetal long bone organ culture system, a bone marrow culture system, and a coculture system of primary osteoblastic cell populations and spleen cells. In the organ culture system, recombinant human IL-1 alpha (rhIL-1 alpha) increased both bone resorption and osteoclast number. Both were partially suppressed in the presence of indomethacin. In the marrow culture, both rhIL-1 alpha and rhIL-1 beta stimulated osteoclastlike cell formation, which was completely inhibited by adding indomethacin concurrently. Furthermore, there was a good correlation between the number of osteoclastlike cells formed and the amount of prostaglandin E2 (PGE2) released into the culture media. This indicates that PGE2 is involved in the mechanism of IL-1-mediated osteoclastlike cell formation. In the coculture of primary osteoblastic cell populations and spleen cells, rhIL-1 again stimulated osteoclastlike cell formation, which was inhibited by adding indomethacin. In the cocultures in which direct interaction between osteoblastic cells and spleen cells was inhibited, PGE2 synthesis was similarly increased but no osteoclastlike cells were formed. These results indicate that IL-1 induces osteoclast formation by a mechanism involving PG (most likely PGE2). Furthermore, direct interaction between osteoclast progenitors and osteoblastic cells is required in the osteoclast recruitment induced by IL-1." @default.
• W2045962246 created "2016-06-24" @default.
• W2045962246 creator A5002464903 @default.
• W2045962246 creator A5002817755 @default.
• W2045962246 creator A5034320377 @default.
• W2045962246 creator A5046699754 @default.
• W2045962246 creator A5049808190 @default.
• W2045962246 creator A5054636847 @default.
• W2045962246 creator A5055741008 @default.
• W2045962246 creator A5074972223 @default.
• W2045962246 date "2009-12-03" @default.
• W2045962246 modified "2023-09-26" @default.
• W2045962246 title "Role of prostaglandins in interleukin-1-induced bone resorption in mice in vitro" @default.
• W2045962246 cites W1537068964 @default.
• W2045962246 cites W1578438134 @default.
• W2045962246 cites W1588586232 @default.
• W2045962246 cites W1848552725 @default.
• W2045962246 cites W1965405390 @default.
• W2045962246 cites W1969481354 @default.
• W2045962246 cites W1972455777 @default.
• W2045962246 cites W1975331230 @default.
• W2045962246 cites W1975587041 @default.
• W2045962246 cites W1977553486 @default.
• W2045962246 cites W1980786945 @default.
• W2045962246 cites W1987568997 @default.
• W2045962246 cites W1991367605 @default.
• W2045962246 cites W1996706666 @default.
• W2045962246 cites W2022087872 @default.
• W2045962246 cites W2025572360 @default.
• W2045962246 cites W2026080578 @default.
• W2045962246 cites W2030261305 @default.
• W2045962246 cites W2043651158 @default.
• W2045962246 cites W2047888347 @default.
• W2045962246 cites W2053034249 @default.
• W2045962246 cites W2078078658 @default.
• W2045962246 cites W2078236994 @default.
• W2045962246 cites W2082967865 @default.
• W2045962246 cites W2084236074 @default.
• W2045962246 cites W2088073016 @default.
• W2045962246 cites W2101191242 @default.
• W2045962246 cites W2102285032 @default.
• W2045962246 cites W2131068682 @default.
• W2045962246 cites W2140039015 @default.
• W2045962246 cites W4313354158 @default.
• W2045962246 doi "https://doi.org/10.1002/jbmr.5650060212" @default.
• W2045962246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2028836" @default.
• W2045962246 hasPublicationYear "2009" @default.
• W2045962246 type Work @default.
• W2045962246 sameAs 2045962246 @default.
• W2045962246 citedByCount "226" @default.
• W2045962246 countsByYear W20459622462012 @default.
• W2045962246 countsByYear W20459622462013 @default.
• W2045962246 countsByYear W20459622462014 @default.
• W2045962246 countsByYear W20459622462015 @default.
• W2045962246 countsByYear W20459622462016 @default.
• W2045962246 countsByYear W20459622462017 @default.
• W2045962246 countsByYear W20459622462019 @default.
• W2045962246 countsByYear W20459622462020 @default.
• W2045962246 countsByYear W20459622462021 @default.
• W2045962246 countsByYear W20459622462022 @default.
• W2045962246 countsByYear W20459622462023 @default.
• W2045962246 crossrefType "journal-article" @default.
• W2045962246 hasAuthorship W2045962246A5002464903 @default.
• W2045962246 hasAuthorship W2045962246A5002817755 @default.
• W2045962246 hasAuthorship W2045962246A5034320377 @default.
• W2045962246 hasAuthorship W2045962246A5046699754 @default.
• W2045962246 hasAuthorship W2045962246A5049808190 @default.
• W2045962246 hasAuthorship W2045962246A5054636847 @default.
• W2045962246 hasAuthorship W2045962246A5055741008 @default.
• W2045962246 hasAuthorship W2045962246A5074972223 @default.
• W2045962246 hasConcept C126322002 @default.
• W2045962246 hasConcept C134018914 @default.
• W2045962246 hasConcept C146562846 @default.
• W2045962246 hasConcept C185592680 @default.
• W2045962246 hasConcept C202751555 @default.
• W2045962246 hasConcept C2776033226 @default.
• W2045962246 hasConcept C2777956040 @default.
• W2045962246 hasConcept C2780007613 @default.
• W2045962246 hasConcept C2780931953 @default.
• W2045962246 hasConcept C28483552 @default.
• W2045962246 hasConcept C54355233 @default.
• W2045962246 hasConcept C55493867 @default.
• W2045962246 hasConcept C673006 @default.
• W2045962246 hasConcept C71924100 @default.
• W2045962246 hasConcept C81885089 @default.
• W2045962246 hasConcept C86803240 @default.
• W2045962246 hasConcept C95444343 @default.
• W2045962246 hasConceptScore W2045962246C126322002 @default.
• W2045962246 hasConceptScore W2045962246C134018914 @default.
• W2045962246 hasConceptScore W2045962246C146562846 @default.
• W2045962246 hasConceptScore W2045962246C185592680 @default.
• W2045962246 hasConceptScore W2045962246C202751555 @default.
• W2045962246 hasConceptScore W2045962246C2776033226 @default.
• W2045962246 hasConceptScore W2045962246C2777956040 @default.
• W2045962246 hasConceptScore W2045962246C2780007613 @default.
• W2045962246 hasConceptScore W2045962246C2780931953 @default.
• W2045962246 hasConceptScore W2045962246C28483552 @default.
• W2045962246 hasConceptScore W2045962246C54355233 @default.

• next