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- W2045964254 abstract "Deregulation of c-myc expression in association with chromosomal translocations occurs in over 95% of murine plasmacytomas, rat immunocytomas, and human Burkitt lymphomas. Infection with a murine retrovirus (J-3) containing an avian v-myc rapidly induced plasmacytomas in pristane-primed BALB/cAn mice. Only 17% of the induced plasmacytomas that were karyotyped showed the characteristic chromosomal translocations involving the c-myc locus. Instead, all of the translocation-negative tumors demonstrated characteristic J-3 virus integration sites that were actively transcribed. Thus, the high levels of v-myc expression have replaced the requirement for chromosomal translocation in plasmacytomagenesis and accelerated the process of transformation." @default.
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- W2045964254 date "1987-02-13" @default.
- W2045964254 modified "2023-10-03" @default.
- W2045964254 title "Avian v-<i>myc</i>Replaces Chromosomal Translocation in Murine Plasmacytomagenesis" @default.
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- W2045964254 doi "https://doi.org/10.1126/science.3810165" @default.
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