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• W2045970981 abstract "The feasibility of global polio eradication is being questioned as a result of continued transmission in a few localities that act as sources for outbreaks elsewhere. Perhaps the greatest challenge is in India, where transmission has persisted in Uttar Pradesh and Bihar despite high coverage with multiple doses of vaccine. We estimate key parameters governing the seasonal epidemics in these areas and show that high population density and poor sanitation cause persistence by not only facilitating transmission of poliovirus but also severely compromising the efficacy of the trivalent vaccine. We analyze strategies to counteract this and show that switching to monovalent vaccine may finally interrupt virus transmission." @default.
• W2045970981 created "2016-06-24" @default.
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• W2045970981 date "2006-11-17" @default.
• W2045970981 modified "2023-10-14" @default.
• W2045970981 title "New Strategies for the Elimination of Polio from India" @default.
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• W2045970981 doi "https://doi.org/10.1126/science.1130388" @default.
• W2045970981 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17110580" @default.
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