Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045971401> ?p ?o ?g. }
- W2045971401 endingPage "499" @default.
- W2045971401 startingPage "494" @default.
- W2045971401 abstract "The conversion of one cell type to another is defined as metaplasia (or sometimes it is referred to as transdifferentiation or cellular reprogramming). Metaplasia is important clinically and may predispose to the development of cancer. Barrett's metaplasia is one such example and is the focus of the present review. Barrett's is a pathological condition in which the normal oesophageal stratified squamous epithelium is replaced by intestinal-type columnar epithelium and is associated with gastro-oesophageal reflux disease. The appearance of columnar epithelium in the oesophagus predisposes to the development of adenocarcinoma. Herein we review the latest evidence on the cellular origin of Barrett's metaplasia. Until recently it was thought that the cellular origin of the columnar epithelium was from a pre-existing cell within the oesophagus. However, recent evidence suggests that this may not be the case. Instead two recent publications indicate that the columnar cells may migrate from a site distal to the oesophagus. These new data contravene our current understanding of metaplasia and raise important questions about the cellular origin of cancer." @default.
- W2045971401 created "2016-06-24" @default.
- W2045971401 creator A5007310050 @default.
- W2045971401 creator A5074856694 @default.
- W2045971401 date "2012-10-01" @default.
- W2045971401 modified "2023-10-17" @default.
- W2045971401 title "Barrett's metaplasia as a paradigm for understanding the development of cancer" @default.
- W2045971401 cites W1482923899 @default.
- W2045971401 cites W1527547321 @default.
- W2045971401 cites W1534987406 @default.
- W2045971401 cites W1584759442 @default.
- W2045971401 cites W1587712169 @default.
- W2045971401 cites W1885130542 @default.
- W2045971401 cites W1973546377 @default.
- W2045971401 cites W1980254549 @default.
- W2045971401 cites W1982603620 @default.
- W2045971401 cites W1986826672 @default.
- W2045971401 cites W1992683009 @default.
- W2045971401 cites W2000854021 @default.
- W2045971401 cites W2007043238 @default.
- W2045971401 cites W2010807493 @default.
- W2045971401 cites W2014938226 @default.
- W2045971401 cites W2016821473 @default.
- W2045971401 cites W2017184561 @default.
- W2045971401 cites W2023770280 @default.
- W2045971401 cites W2025727818 @default.
- W2045971401 cites W2028337921 @default.
- W2045971401 cites W2033014144 @default.
- W2045971401 cites W2055624728 @default.
- W2045971401 cites W2060823106 @default.
- W2045971401 cites W2066474485 @default.
- W2045971401 cites W2066795324 @default.
- W2045971401 cites W2075890816 @default.
- W2045971401 cites W2080988481 @default.
- W2045971401 cites W2081716261 @default.
- W2045971401 cites W2085116214 @default.
- W2045971401 cites W2086704402 @default.
- W2045971401 cites W2093198712 @default.
- W2045971401 cites W2097387056 @default.
- W2045971401 cites W2101139097 @default.
- W2045971401 cites W2123274778 @default.
- W2045971401 cites W2143177831 @default.
- W2045971401 cites W2149214251 @default.
- W2045971401 cites W2153027227 @default.
- W2045971401 cites W2168544170 @default.
- W2045971401 cites W2170202550 @default.
- W2045971401 doi "https://doi.org/10.1016/j.gde.2012.08.001" @default.
- W2045971401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22981230" @default.
- W2045971401 hasPublicationYear "2012" @default.
- W2045971401 type Work @default.
- W2045971401 sameAs 2045971401 @default.
- W2045971401 citedByCount "36" @default.
- W2045971401 countsByYear W20459714012013 @default.
- W2045971401 countsByYear W20459714012014 @default.
- W2045971401 countsByYear W20459714012015 @default.
- W2045971401 countsByYear W20459714012016 @default.
- W2045971401 countsByYear W20459714012017 @default.
- W2045971401 countsByYear W20459714012018 @default.
- W2045971401 countsByYear W20459714012019 @default.
- W2045971401 countsByYear W20459714012020 @default.
- W2045971401 countsByYear W20459714012021 @default.
- W2045971401 countsByYear W20459714012023 @default.
- W2045971401 crossrefType "journal-article" @default.
- W2045971401 hasAuthorship W2045971401A5007310050 @default.
- W2045971401 hasAuthorship W2045971401A5074856694 @default.
- W2045971401 hasConcept C121608353 @default.
- W2045971401 hasConcept C142724271 @default.
- W2045971401 hasConcept C1491633281 @default.
- W2045971401 hasConcept C2776497702 @default.
- W2045971401 hasConcept C2779357193 @default.
- W2045971401 hasConcept C2779636128 @default.
- W2045971401 hasConcept C2781182431 @default.
- W2045971401 hasConcept C28328180 @default.
- W2045971401 hasConcept C502942594 @default.
- W2045971401 hasConcept C529295009 @default.
- W2045971401 hasConcept C54355233 @default.
- W2045971401 hasConcept C60870556 @default.
- W2045971401 hasConcept C71924100 @default.
- W2045971401 hasConcept C77255625 @default.
- W2045971401 hasConcept C86803240 @default.
- W2045971401 hasConcept C95444343 @default.
- W2045971401 hasConceptScore W2045971401C121608353 @default.
- W2045971401 hasConceptScore W2045971401C142724271 @default.
- W2045971401 hasConceptScore W2045971401C1491633281 @default.
- W2045971401 hasConceptScore W2045971401C2776497702 @default.
- W2045971401 hasConceptScore W2045971401C2779357193 @default.
- W2045971401 hasConceptScore W2045971401C2779636128 @default.
- W2045971401 hasConceptScore W2045971401C2781182431 @default.
- W2045971401 hasConceptScore W2045971401C28328180 @default.
- W2045971401 hasConceptScore W2045971401C502942594 @default.
- W2045971401 hasConceptScore W2045971401C529295009 @default.
- W2045971401 hasConceptScore W2045971401C54355233 @default.
- W2045971401 hasConceptScore W2045971401C60870556 @default.
- W2045971401 hasConceptScore W2045971401C71924100 @default.
- W2045971401 hasConceptScore W2045971401C77255625 @default.
- W2045971401 hasConceptScore W2045971401C86803240 @default.
- W2045971401 hasConceptScore W2045971401C95444343 @default.
- W2045971401 hasIssue "5" @default.