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• W2045972345 abstract "Estrogen in many forms and doses can improve or maintain bone mass at all stages in postmenopausal life. Clinical trial data consistent with this effect include several small studies evaluating vertebral deformity and one study evaluating non-vertebral fracture. Two studies in patients with established cardiovascular disease have shown conflicting results on estrogen's ability to reduce fracture risk. Use of estrogen to prevent osteoporotic fracture must be considered in light of the multisystemic effects, which include effects on the cardiovascular, central nervous, urogynecologic, and gastrointestinal systems as well as on the breasts. Intervention with estrogens or hormone replacement therapy has been considered to be the gold standard for prevention and treatment of osteoporosis among postmenopausal women. The relative paucity of fracture outcome data from randomized clinical trials, however, led to the recent decision by the FDA to rescind estrogen's osteoporosis treatment indication. With respect to bone, estrogens are now indicated in the United States only for osteoporosis prevention. There is also an increasing awareness that estrogens may be important in osteoporosis among males. The development of novel effective therapeutic approaches to osteoporosis underscores the importance of understanding both the mechanism of estrogen's effects and also the possible effectiveness of estrogen intervention in fracture reduction." @default.
• W2045972345 created "2016-06-24" @default.
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• W2045972345 date "2001-01-01" @default.
• W2045972345 modified "2023-09-27" @default.
• W2045972345 title "Estrogens and Osteoporosis" @default.
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• W2045972345 doi "https://doi.org/10.1016/b978-012470862-4/50070-2" @default.
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