FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045973879> ?p ?o ?g. }

• W2045973879 endingPage "139" @default.
• W2045973879 startingPage "135" @default.
• W2045973879 abstract "Evidence is presented for regulation by insulin of pyruvate dehydrogenase (pdh) interconversion in rat heart muscle in vivo and in vitro. In the alloxan diabetic rat the active (dephospho) enzyme amounted only to 12% of total PDH and was restored to 42% by insulin. Antilipolytic treatment of the dibetic animals was ineffective, indicating that the action of insulin was independent of a lowering of plasma non-esterified fatty acid concentration. On perfusion of isolated hearts from diabetic rats in the presence of glucose the proportion of pyruvate dehydrogenase in the active form remained low but was fully restored upon addition of insulin (2mU/ml) to the medium. No effect of insulin was obtained in the absence of glucose. The correlation between the rate of pyruvate decarboxylation in the perfused heart and of pyruvate dehydrogenase activity, in vitro, suggests that in the diabetic heart the entry of pyruvate into the citric acid cycle is largely controlled by covalent modification of the pyruvate dehydrogenase complex rather than by feedback inhibition. The possible role of insulin therein is discussed." @default.
• W2045973879 created "2016-06-24" @default.
• W2045973879 creator A5003381823 @default.
• W2045973879 creator A5046052449 @default.
• W2045973879 creator A5059844871 @default.
• W2045973879 creator A5080970123 @default.
• W2045973879 date "1978-02-01" @default.
• W2045973879 modified "2023-09-23" @default.
• W2045973879 title "The effect of insulin on pyruvate dehydrogenase interconversion in heart muscle of alloxan-diabetic rats" @default.
• W2045973879 cites W1505838412 @default.
• W2045973879 cites W1514690741 @default.
• W2045973879 cites W1531062343 @default.
• W2045973879 cites W1564309614 @default.
• W2045973879 cites W1565056239 @default.
• W2045973879 cites W1759931938 @default.
• W2045973879 cites W183190858 @default.
• W2045973879 cites W193452758 @default.
• W2045973879 cites W1951915438 @default.
• W2045973879 cites W1966809029 @default.
• W2045973879 cites W1973345499 @default.
• W2045973879 cites W1986519363 @default.
• W2045973879 cites W1997470498 @default.
• W2045973879 cites W2026912546 @default.
• W2045973879 cites W2027316768 @default.
• W2045973879 cites W2045853510 @default.
• W2045973879 cites W2052783498 @default.
• W2045973879 cites W2056179179 @default.
• W2045973879 cites W2061202598 @default.
• W2045973879 cites W2067812271 @default.
• W2045973879 cites W2073992275 @default.
• W2045973879 cites W2077416701 @default.
• W2045973879 cites W2158516240 @default.
• W2045973879 cites W2211459314 @default.
• W2045973879 cites W2318787732 @default.
• W2045973879 cites W2319953554 @default.
• W2045973879 cites W2331475307 @default.
• W2045973879 cites W2335088247 @default.
• W2045973879 cites W2341575055 @default.
• W2045973879 cites W2414794680 @default.
• W2045973879 cites W2432195370 @default.
• W2045973879 cites W2443129672 @default.
• W2045973879 doi "https://doi.org/10.1007/bf01263452" @default.
• W2045973879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/631458" @default.
• W2045973879 hasPublicationYear "1978" @default.
• W2045973879 type Work @default.
• W2045973879 sameAs 2045973879 @default.
• W2045973879 citedByCount "19" @default.
• W2045973879 crossrefType "journal-article" @default.
• W2045973879 hasAuthorship W2045973879A5003381823 @default.
• W2045973879 hasAuthorship W2045973879A5046052449 @default.
• W2045973879 hasAuthorship W2045973879A5059844871 @default.
• W2045973879 hasAuthorship W2045973879A5080970123 @default.
• W2045973879 hasBestOaLocation W20459738791 @default.
• W2045973879 hasConcept C101972281 @default.
• W2045973879 hasConcept C126093377 @default.
• W2045973879 hasConcept C126322002 @default.
• W2045973879 hasConcept C134018914 @default.
• W2045973879 hasConcept C140137476 @default.
• W2045973879 hasConcept C165135838 @default.
• W2045973879 hasConcept C181199279 @default.
• W2045973879 hasConcept C185592680 @default.
• W2045973879 hasConcept C190098323 @default.
• W2045973879 hasConcept C20904676 @default.
• W2045973879 hasConcept C2779306644 @default.
• W2045973879 hasConcept C2781005915 @default.
• W2045973879 hasConcept C55493867 @default.
• W2045973879 hasConcept C555293320 @default.
• W2045973879 hasConcept C62231903 @default.
• W2045973879 hasConcept C71924100 @default.
• W2045973879 hasConcept C80097345 @default.
• W2045973879 hasConcept C86803240 @default.
• W2045973879 hasConcept C88099638 @default.
• W2045973879 hasConcept C9506865 @default.
• W2045973879 hasConceptScore W2045973879C101972281 @default.
• W2045973879 hasConceptScore W2045973879C126093377 @default.
• W2045973879 hasConceptScore W2045973879C126322002 @default.
• W2045973879 hasConceptScore W2045973879C134018914 @default.
• W2045973879 hasConceptScore W2045973879C140137476 @default.
• W2045973879 hasConceptScore W2045973879C165135838 @default.
• W2045973879 hasConceptScore W2045973879C181199279 @default.
• W2045973879 hasConceptScore W2045973879C185592680 @default.
• W2045973879 hasConceptScore W2045973879C190098323 @default.
• W2045973879 hasConceptScore W2045973879C20904676 @default.
• W2045973879 hasConceptScore W2045973879C2779306644 @default.
• W2045973879 hasConceptScore W2045973879C2781005915 @default.
• W2045973879 hasConceptScore W2045973879C55493867 @default.
• W2045973879 hasConceptScore W2045973879C555293320 @default.
• W2045973879 hasConceptScore W2045973879C62231903 @default.
• W2045973879 hasConceptScore W2045973879C71924100 @default.
• W2045973879 hasConceptScore W2045973879C80097345 @default.
• W2045973879 hasConceptScore W2045973879C86803240 @default.
• W2045973879 hasConceptScore W2045973879C88099638 @default.
• W2045973879 hasConceptScore W2045973879C9506865 @default.
• W2045973879 hasIssue "2" @default.
• W2045973879 hasLocation W20459738791 @default.
• W2045973879 hasLocation W20459738792 @default.
• W2045973879 hasOpenAccess W2045973879 @default.
• W2045973879 hasPrimaryLocation W20459738791 @default.

• next