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- W2045978324 abstract "Two variants of Annexin A5 (Cys2-AnxA5 and Cys165-AnxA5) were labelled with Gallium-68 in order to evaluate their biological properties. Biodistribution and pharmacokinetics of the radiotracers were studied with μPET in healthy mice and in a mouse model of hepatic apoptosis. μPET imaging after IV injection of the tracers in combination with μMRI was performed in Daudi tumor bearing mice before and after treatment with a combination of chemotherapy and radiotherapy. The biodistribution data indicated a fast urinary clearance with only minor hepatobilliary clearance, although a high retention in the kidneys was observed. Animals treated with anti-Fas showed a 3 to 8 times higher liver uptake as compared to healthy animals. Tumor uptake of 68Ga-Cys2-AnxA5 and 68Ga-Cys165-AnxA5 was low but significantly increased after therapy. Both 68Ga-Cys2-AnxA5 and 68Ga-Cys165-AnxA5 show a clear binding to apoptotic cells and are promising tracers for rapid evaluation of cancer therapy." @default.
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- W2045978324 date "2011-04-01" @default.
- W2045978324 modified "2023-10-14" @default.
- W2045978324 title "Site-specific 68Ga-labeled Annexin A5 as a PET imaging agent for apoptosis" @default.
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- W2045978324 doi "https://doi.org/10.1016/j.nucmedbio.2010.09.008" @default.
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