FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045982793> ?p ?o ?g. }

• W2045982793 endingPage "2136" @default.
• W2045982793 startingPage "2130" @default.
• W2045982793 abstract "In a previous study, it was shown that the Kaposi sarcoma–associated herpesvirus (KSHV) was specifically associated with monotypic (IgMλ) plasmablasts in multicentric Castleman disease (MCD). The plasmablasts occur as isolated cells in the mantle zone of B-cell follicles but may form microlymphoma or frank plasmablastic lymphoma. To determine the clonality and cellular origin of the monotypic plasmablasts, the rearranged Ig genes in 13 patients with KSHV-related MCD, including 8 cases with microlymphomas and 2 with frank lymphomas, were studied. To investigate the role of the interleukin 6 (IL-6) receptor signaling in the pathogenesis of MCD and associated lymphoproliferative disorders, viral IL-6 and human IL-6 receptor expression was examined. KSHV-positive plasmablasts were polyclonal in MCD-involved lymphoid tissues in all cases and microlymphomas in 6 of 8 cases. Monoclonal KSHV-positive plasmablasts were seen in microlymphomas of 2 cases and in both frank lymphomas. Despite their mature phenotype, KSHV-positive plasmablasts did not harbor somatic mutations in the rearranged Ig genes, indicating origination from naive B cells. Viral IL-6 was expressed in 10% to 15% of KSHV-positive plasmablasts, whereas the human IL-6 receptor was expressed in most KSHV-positive cells. Thus, KSHV infects monotypic but polyclonal naive B cells and is associated with a range of lymphoproliferative disorders from polyclonal isolated plasmablasts and microlymphomas to monoclonal microlymphoma and frank plasmablastic lymphomas in MCD patients. Activation of the IL-6 receptor signaling pathway may play a role in differentiation of KSHV-infected naive B cells into plasmablasts and development of lymphoproliferative lesions." @default.
• W2045982793 created "2016-06-24" @default.
• W2045982793 creator A5001231520 @default.
• W2045982793 creator A5002852999 @default.
• W2045982793 creator A5004200273 @default.
• W2045982793 creator A5015762331 @default.
• W2045982793 creator A5020421276 @default.
• W2045982793 creator A5031600864 @default.
• W2045982793 creator A5042447894 @default.
• W2045982793 creator A5046629044 @default.
• W2045982793 creator A5046807661 @default.
• W2045982793 creator A5060931224 @default.
• W2045982793 date "2001-04-01" @default.
• W2045982793 modified "2023-10-17" @default.
• W2045982793 title "Kaposi sarcoma-associated herpesvirus infects monotypic (IgMlambda) but polyclonal naive B cells in Castleman disease and associated lymphoproliferative disorders" @default.
• W2045982793 cites W123913429 @default.
• W2045982793 cites W1512840405 @default.
• W2045982793 cites W1604210388 @default.
• W2045982793 cites W1632068222 @default.
• W2045982793 cites W1635039246 @default.
• W2045982793 cites W1673837423 @default.
• W2045982793 cites W1679234458 @default.
• W2045982793 cites W17455494 @default.
• W2045982793 cites W1814688818 @default.
• W2045982793 cites W1874138720 @default.
• W2045982793 cites W188936430 @default.
• W2045982793 cites W1946172505 @default.
• W2045982793 cites W1970768125 @default.
• W2045982793 cites W1975100378 @default.
• W2045982793 cites W1982047106 @default.
• W2045982793 cites W1987735322 @default.
• W2045982793 cites W1991782104 @default.
• W2045982793 cites W2004263085 @default.
• W2045982793 cites W2006099833 @default.
• W2045982793 cites W2021624909 @default.
• W2045982793 cites W2032387120 @default.
• W2045982793 cites W2041811554 @default.
• W2045982793 cites W2042156273 @default.
• W2045982793 cites W2051260092 @default.
• W2045982793 cites W2054911290 @default.
• W2045982793 cites W2066418230 @default.
• W2045982793 cites W2076976507 @default.
• W2045982793 cites W2086703018 @default.
• W2045982793 cites W2089470376 @default.
• W2045982793 cites W2090702421 @default.
• W2045982793 cites W2097465667 @default.
• W2045982793 cites W2102188264 @default.
• W2045982793 cites W2104579398 @default.
• W2045982793 cites W2109249128 @default.
• W2045982793 cites W2121556311 @default.
• W2045982793 cites W2122006616 @default.
• W2045982793 cites W2132182183 @default.
• W2045982793 cites W2140611891 @default.
• W2045982793 cites W2160409151 @default.
• W2045982793 cites W2160508776 @default.
• W2045982793 cites W2166187451 @default.
• W2045982793 cites W2280492586 @default.
• W2045982793 cites W2318167018 @default.
• W2045982793 cites W2328705550 @default.
• W2045982793 cites W2417416303 @default.
• W2045982793 cites W1606363524 @default.
• W2045982793 doi "https://doi.org/10.1182/blood.v97.7.2130" @default.
• W2045982793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11264181" @default.
• W2045982793 hasPublicationYear "2001" @default.
• W2045982793 type Work @default.
• W2045982793 sameAs 2045982793 @default.
• W2045982793 citedByCount "338" @default.
• W2045982793 countsByYear W20459827932012 @default.
• W2045982793 countsByYear W20459827932013 @default.
• W2045982793 countsByYear W20459827932014 @default.
• W2045982793 countsByYear W20459827932015 @default.
• W2045982793 countsByYear W20459827932016 @default.
• W2045982793 countsByYear W20459827932017 @default.
• W2045982793 countsByYear W20459827932018 @default.
• W2045982793 countsByYear W20459827932019 @default.
• W2045982793 countsByYear W20459827932020 @default.
• W2045982793 countsByYear W20459827932021 @default.
• W2045982793 countsByYear W20459827932022 @default.
• W2045982793 countsByYear W20459827932023 @default.
• W2045982793 crossrefType "journal-article" @default.
• W2045982793 hasAuthorship W2045982793A5001231520 @default.
• W2045982793 hasAuthorship W2045982793A5002852999 @default.
• W2045982793 hasAuthorship W2045982793A5004200273 @default.
• W2045982793 hasAuthorship W2045982793A5015762331 @default.
• W2045982793 hasAuthorship W2045982793A5020421276 @default.
• W2045982793 hasAuthorship W2045982793A5031600864 @default.
• W2045982793 hasAuthorship W2045982793A5042447894 @default.
• W2045982793 hasAuthorship W2045982793A5046629044 @default.
• W2045982793 hasAuthorship W2045982793A5046807661 @default.
• W2045982793 hasAuthorship W2045982793A5060931224 @default.
• W2045982793 hasBestOaLocation W20459827931 @default.
• W2045982793 hasConcept C142724271 @default.
• W2045982793 hasConcept C159047783 @default.
• W2045982793 hasConcept C159654299 @default.
• W2045982793 hasConcept C163864487 @default.
• W2045982793 hasConcept C203014093 @default.
• W2045982793 hasConcept C2776054410 @default.
• W2045982793 hasConcept C2776995267 @default.

• next