FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045985535> ?p ?o ?g. }

• W2045985535 endingPage "911" @default.
• W2045985535 startingPage "897" @default.
• W2045985535 abstract "As the premalignant lesion of human esophageal adenocarcinoma (EAC), Barrett’s esophagus (BE) is characterized by intestinal metaplasia in the normal esophagus (NE). Gene expression profiling with microarray and serial analysis of gene expression (SAGE) may help us understand the potential molecular mechanism of human BE. We analyzed three microarray datasets (two cDNA arrays and one oligonucleotide array) and one SAGE dataset with statistical tools, significance analysis of microarrays (SAM) and SAGE(Poisson), to identify individual genes differentially expressed in BE. Gene set enrichment analysis (GSEA) was used to identify a priori defined sets of genes that were differentially expressed. These gene sets were grouped according to either certain signaling pathways (GSEA curated), or the presence of consensus binding sequences of known transcription factors (GSEA motif). Immunohistochemical staining (IHC) was used to validate differential gene expression. Both SAM and SAGE(Poisson) identified 68 differentially expressed genes (55 BE genes and 13 NE genes) with an arbitrary cutoff ratio (≥4-fold). With IHC on matched pairs of NE and BE tissues from 6 patients, these genes were grouped into 6 categories: category I (25 genes only expressed in BE), category II (5 genes only expressed in NE), category III (8 genes expressed more in BE than in NE), and category IV (2 genes expressed more in NE than in BE). Differential expression of the remaining genes was not confirmed by IHC either due to false discovery (category V), or lack of proper antibodies (category VI). Besides individual genes, the TGFβ pathway and several transcription factors (CDX2, HNF1, and HNF4) were identified by GSEA as enriched pathways and motifs in BE. Apart from 9 target genes known to be up-regulated in BE, IHC staining confirmed up-regulation of 19 additional CDX1 and CDX2 target genes in BE. Our data suggested an important role of CDX1 and CDX2 in the development of BE. The IHC-confirmed gene list will lead to future studies on the molecular mechanism of BE." @default.
• W2045985535 created "2016-06-24" @default.
• W2045985535 creator A5004380209 @default.
• W2045985535 creator A5004533335 @default.
• W2045985535 creator A5005139471 @default.
• W2045985535 creator A5028921014 @default.
• W2045985535 creator A5036472571 @default.
• W2045985535 creator A5060775764 @default.
• W2045985535 creator A5085567931 @default.
• W2045985535 creator A5089702792 @default.
• W2045985535 date "2009-05-27" @default.
• W2045985535 modified "2023-10-17" @default.
• W2045985535 title "Differential gene expression in normal esophagus and Barrett’s esophagus" @default.
• W2045985535 cites W1493267183 @default.
• W2045985535 cites W1974920067 @default.
• W2045985535 cites W1978558236 @default.
• W2045985535 cites W1980648321 @default.
• W2045985535 cites W1996209724 @default.
• W2045985535 cites W2001556983 @default.
• W2045985535 cites W2005803469 @default.
• W2045985535 cites W2007120802 @default.
• W2045985535 cites W2013351311 @default.
• W2045985535 cites W2020104179 @default.
• W2045985535 cites W2023189561 @default.
• W2045985535 cites W2024121049 @default.
• W2045985535 cites W2024274322 @default.
• W2045985535 cites W2031078194 @default.
• W2045985535 cites W2048303910 @default.
• W2045985535 cites W2050206319 @default.
• W2045985535 cites W2050719264 @default.
• W2045985535 cites W2065762573 @default.
• W2045985535 cites W2067746951 @default.
• W2045985535 cites W2069139878 @default.
• W2045985535 cites W2092489109 @default.
• W2045985535 cites W2097194697 @default.
• W2045985535 cites W2097473265 @default.
• W2045985535 cites W2098771435 @default.
• W2045985535 cites W2099967654 @default.
• W2045985535 cites W2100024199 @default.
• W2045985535 cites W2106033575 @default.
• W2045985535 cites W2109413027 @default.
• W2045985535 cites W2111844634 @default.
• W2045985535 cites W2112939302 @default.
• W2045985535 cites W2125196373 @default.
• W2045985535 cites W2127829747 @default.
• W2045985535 cites W2128266727 @default.
• W2045985535 cites W2132322909 @default.
• W2045985535 cites W2137780921 @default.
• W2045985535 cites W2140158828 @default.
• W2045985535 cites W2142070680 @default.
• W2045985535 cites W2143177831 @default.
• W2045985535 cites W2144285391 @default.
• W2045985535 cites W2150088457 @default.
• W2045985535 cites W2151322467 @default.
• W2045985535 cites W2153265335 @default.
• W2045985535 cites W2153414961 @default.
• W2045985535 cites W2157293547 @default.
• W2045985535 cites W2157473448 @default.
• W2045985535 cites W2162592909 @default.
• W2045985535 cites W2171057075 @default.
• W2045985535 cites W2315386492 @default.
• W2045985535 cites W368485892 @default.
• W2045985535 cites W4294107304 @default.
• W2045985535 doi "https://doi.org/10.1007/s00535-009-0082-2" @default.
• W2045985535 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3811010" @default.
• W2045985535 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19468668" @default.
• W2045985535 hasPublicationYear "2009" @default.
• W2045985535 type Work @default.
• W2045985535 sameAs 2045985535 @default.
• W2045985535 citedByCount "41" @default.
• W2045985535 countsByYear W20459855352012 @default.
• W2045985535 countsByYear W20459855352013 @default.
• W2045985535 countsByYear W20459855352014 @default.
• W2045985535 countsByYear W20459855352015 @default.
• W2045985535 countsByYear W20459855352016 @default.
• W2045985535 countsByYear W20459855352017 @default.
• W2045985535 countsByYear W20459855352018 @default.
• W2045985535 countsByYear W20459855352019 @default.
• W2045985535 countsByYear W20459855352020 @default.
• W2045985535 countsByYear W20459855352021 @default.
• W2045985535 countsByYear W20459855352022 @default.
• W2045985535 countsByYear W20459855352023 @default.
• W2045985535 crossrefType "journal-article" @default.
• W2045985535 hasAuthorship W2045985535A5004380209 @default.
• W2045985535 hasAuthorship W2045985535A5004533335 @default.
• W2045985535 hasAuthorship W2045985535A5005139471 @default.
• W2045985535 hasAuthorship W2045985535A5028921014 @default.
• W2045985535 hasAuthorship W2045985535A5036472571 @default.
• W2045985535 hasAuthorship W2045985535A5060775764 @default.
• W2045985535 hasAuthorship W2045985535A5085567931 @default.
• W2045985535 hasAuthorship W2045985535A5089702792 @default.
• W2045985535 hasBestOaLocation W20459855352 @default.
• W2045985535 hasConcept C104317684 @default.
• W2045985535 hasConcept C121608353 @default.
• W2045985535 hasConcept C150194340 @default.
• W2045985535 hasConcept C153911025 @default.
• W2045985535 hasConcept C18431079 @default.
• W2045985535 hasConcept C186836561 @default.

• next