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• W2045987400 abstract "Alzheimer disease is characterized by cerebral Abeta deposition, which we have recently discovered occurs also in the lens as cataracts in Alzheimer disease patients. Here we report the presence of significantly increased cataracts in the lenses of an Abeta-transgenic mouse model for Alzheimer disease and their amelioration upon treatment with EUK-189, a synthetic SOD/catalase mimetic. These data support an oxidative etiology for AD-associated lens cataracts and their potential to be treated preventatively with antioxidants." @default.
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• W2045987400 date "2005-01-15" @default.
• W2045987400 modified "2023-09-25" @default.
• W2045987400 title "Mice transgenic for Alzheimer disease ?-amyloid develop lens cataracts that are rescued by antioxidant treatment" @default.
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• W2045987400 doi "https://doi.org/10.1016/j.freeradbiomed.2004.10.023" @default.
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