Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045989211> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2045989211 endingPage "2864" @default.
- W2045989211 startingPage "2859" @default.
- W2045989211 abstract "This work presents a deterministic non-structured model of the penicillin production process. For the model development were considered Contois growth type model, yield coefficients among growth, substrate and oxygen uptake, production specific rates, endogenous and maintenance metabolism, substrate excess product inibition and hydrolyse from penicillin to peniciloic acid. Volumetric oxygen transfer coefficient was estimated through Reynolds and Power numbers, and apparent viscosity as a cell concentration function, and gasefied fluid power. The operation mode was feed-batch, and the parameters were obtained from the literature. The resulting model was solved by a forth-order Runge-Kutta algorithm. Process productivity optimization was initially made with relation to cell initial concentration, fed-batch flow rate and substrate fed-batch concentration. To carried out this procedure, it was necessary to consider process operating constraints as the bioreactor final volume, dissolved oxygen, cell and substrate concentrations. These operating constraints were computed in relation to productivity through the concept of the penalty functions. Using this procedure, it was possible to obtain the state variables leading to the best productivity and taking into account the constraints, through an optimization algorithm based on the modified simplex method. With fixed optimal values of the cell and substrate feed-batch concentrations, feed-batch flow rate strategies of two types were performed: (1) first, second, and third order polinomial functions with six hours samples were used, and (2) with independent values with six and twelve hours samples. The optimization algorithm was the same as above mentioned. With the proposed methodology it was possible to obtain the operating variables so that the best productivity with state constraints can be achieved for the production phase of the penicillin process." @default.
- W2045989211 created "2016-06-24" @default.
- W2045989211 creator A5064159916 @default.
- W2045989211 creator A5085410595 @default.
- W2045989211 date "1996-06-01" @default.
- W2045989211 modified "2023-10-18" @default.
- W2045989211 title "Optimal feed rates strategies with operating constraints for the penicillin production process" @default.
- W2045989211 cites W2015454007 @default.
- W2045989211 cites W2048397197 @default.
- W2045989211 cites W2080837112 @default.
- W2045989211 cites W2097465913 @default.
- W2045989211 cites W2098077707 @default.
- W2045989211 cites W2098914094 @default.
- W2045989211 cites W2100933114 @default.
- W2045989211 cites W2111436190 @default.
- W2045989211 cites W2131021484 @default.
- W2045989211 cites W2141557757 @default.
- W2045989211 cites W2149084885 @default.
- W2045989211 cites W2162443713 @default.
- W2045989211 cites W2167090154 @default.
- W2045989211 doi "https://doi.org/10.1016/0009-2509(96)00165-0" @default.
- W2045989211 hasPublicationYear "1996" @default.
- W2045989211 type Work @default.
- W2045989211 sameAs 2045989211 @default.
- W2045989211 citedByCount "13" @default.
- W2045989211 countsByYear W20459892112017 @default.
- W2045989211 countsByYear W20459892112023 @default.
- W2045989211 crossrefType "journal-article" @default.
- W2045989211 hasAuthorship W2045989211A5064159916 @default.
- W2045989211 hasAuthorship W2045989211A5085410595 @default.
- W2045989211 hasConcept C111368507 @default.
- W2045989211 hasConcept C121332964 @default.
- W2045989211 hasConcept C126255220 @default.
- W2045989211 hasConcept C127313418 @default.
- W2045989211 hasConcept C127413603 @default.
- W2045989211 hasConcept C144521790 @default.
- W2045989211 hasConcept C168170006 @default.
- W2045989211 hasConcept C172120300 @default.
- W2045989211 hasConcept C174802600 @default.
- W2045989211 hasConcept C178790620 @default.
- W2045989211 hasConcept C185592680 @default.
- W2045989211 hasConcept C186060115 @default.
- W2045989211 hasConcept C21880701 @default.
- W2045989211 hasConcept C2777289219 @default.
- W2045989211 hasConcept C2777451570 @default.
- W2045989211 hasConcept C33923547 @default.
- W2045989211 hasConcept C41045048 @default.
- W2045989211 hasConcept C501593827 @default.
- W2045989211 hasConcept C55493867 @default.
- W2045989211 hasConcept C86803240 @default.
- W2045989211 hasConcept C97355855 @default.
- W2045989211 hasConceptScore W2045989211C111368507 @default.
- W2045989211 hasConceptScore W2045989211C121332964 @default.
- W2045989211 hasConceptScore W2045989211C126255220 @default.
- W2045989211 hasConceptScore W2045989211C127313418 @default.
- W2045989211 hasConceptScore W2045989211C127413603 @default.
- W2045989211 hasConceptScore W2045989211C144521790 @default.
- W2045989211 hasConceptScore W2045989211C168170006 @default.
- W2045989211 hasConceptScore W2045989211C172120300 @default.
- W2045989211 hasConceptScore W2045989211C174802600 @default.
- W2045989211 hasConceptScore W2045989211C178790620 @default.
- W2045989211 hasConceptScore W2045989211C185592680 @default.
- W2045989211 hasConceptScore W2045989211C186060115 @default.
- W2045989211 hasConceptScore W2045989211C21880701 @default.
- W2045989211 hasConceptScore W2045989211C2777289219 @default.
- W2045989211 hasConceptScore W2045989211C2777451570 @default.
- W2045989211 hasConceptScore W2045989211C33923547 @default.
- W2045989211 hasConceptScore W2045989211C41045048 @default.
- W2045989211 hasConceptScore W2045989211C501593827 @default.
- W2045989211 hasConceptScore W2045989211C55493867 @default.
- W2045989211 hasConceptScore W2045989211C86803240 @default.
- W2045989211 hasConceptScore W2045989211C97355855 @default.
- W2045989211 hasIssue "11" @default.
- W2045989211 hasLocation W20459892111 @default.
- W2045989211 hasOpenAccess W2045989211 @default.
- W2045989211 hasPrimaryLocation W20459892111 @default.
- W2045989211 hasRelatedWork W1975391289 @default.
- W2045989211 hasRelatedWork W1986025748 @default.
- W2045989211 hasRelatedWork W2088509800 @default.
- W2045989211 hasRelatedWork W2158664501 @default.
- W2045989211 hasRelatedWork W2185491370 @default.
- W2045989211 hasRelatedWork W2535702380 @default.
- W2045989211 hasRelatedWork W2899112040 @default.
- W2045989211 hasRelatedWork W2940953232 @default.
- W2045989211 hasRelatedWork W3215601415 @default.
- W2045989211 hasRelatedWork W4323268242 @default.
- W2045989211 hasVolume "51" @default.
- W2045989211 isParatext "false" @default.
- W2045989211 isRetracted "false" @default.
- W2045989211 magId "2045989211" @default.
- W2045989211 workType "article" @default.