Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045989867> ?p ?o ?g. }
- W2045989867 endingPage "243" @default.
- W2045989867 startingPage "233" @default.
- W2045989867 abstract "Sleep is a fundamental behavior exhibited almost universally throughout the animal kingdom. The required amount and circadian timing of sleep differs greatly between species in accordance with habitats and evolutionary history. The Mexican blind cavefish, <i>Astyanax mexicanus, </i>is a model organism for the study of adaptive morphological and behavioral traits. In addition to loss of eyes and pigmentation, cave populations of <i>A. mexicanus </i>exhibit evolutionarily derived sleep loss and increased vibration attraction behavior, presumably to cope with a nutrient-poor environment. Understanding the neural mechanisms of evolutionarily derived sleep loss in this system may reveal critical insights into the regulation of sleep in vertebrates. Here we report that blockade of β-adrenergic receptors with propranolol rescues the decreased-sleep phenotype of cavefish. This effect was not seen with α-adrenergic antagonists. Treatment with selective β1-, β2-, and β3-antagonists revealed that the increased sleep observed with propranolol could partially be explained via the β1-adrenergic system. Morphological analysis of catecholamine circuitry revealed conservation of gross catecholaminergic neuroanatomy between surface and cave morphs. Taken together, these findings suggest that evolutionarily derived changes in adrenergic signaling underlie the reduced sleep of cave populations." @default.
- W2045989867 created "2016-06-24" @default.
- W2045989867 creator A5023226419 @default.
- W2045989867 creator A5029765045 @default.
- W2045989867 creator A5041865755 @default.
- W2045989867 date "2012-01-01" @default.
- W2045989867 modified "2023-10-17" @default.
- W2045989867 title "β-Adrenergic Signaling Regulates Evolutionarily Derived Sleep Loss in the Mexican Cavefish" @default.
- W2045989867 cites W1495141869 @default.
- W2045989867 cites W1529536724 @default.
- W2045989867 cites W1640809349 @default.
- W2045989867 cites W1897850981 @default.
- W2045989867 cites W1946245799 @default.
- W2045989867 cites W1979267661 @default.
- W2045989867 cites W1988082031 @default.
- W2045989867 cites W1996214950 @default.
- W2045989867 cites W2005434002 @default.
- W2045989867 cites W2005921367 @default.
- W2045989867 cites W2007283165 @default.
- W2045989867 cites W2020291589 @default.
- W2045989867 cites W2021185182 @default.
- W2045989867 cites W2025019596 @default.
- W2045989867 cites W2029483448 @default.
- W2045989867 cites W2032339545 @default.
- W2045989867 cites W2032389394 @default.
- W2045989867 cites W2034450065 @default.
- W2045989867 cites W2044779256 @default.
- W2045989867 cites W2046047992 @default.
- W2045989867 cites W2047578534 @default.
- W2045989867 cites W2060513403 @default.
- W2045989867 cites W2060731374 @default.
- W2045989867 cites W2060886811 @default.
- W2045989867 cites W2063949011 @default.
- W2045989867 cites W2064194489 @default.
- W2045989867 cites W2065122532 @default.
- W2045989867 cites W2066185659 @default.
- W2045989867 cites W2072727594 @default.
- W2045989867 cites W2076834018 @default.
- W2045989867 cites W2076963213 @default.
- W2045989867 cites W2078692552 @default.
- W2045989867 cites W2082057305 @default.
- W2045989867 cites W2083143366 @default.
- W2045989867 cites W2085650296 @default.
- W2045989867 cites W2091148368 @default.
- W2045989867 cites W2093005051 @default.
- W2045989867 cites W2105728643 @default.
- W2045989867 cites W2134943302 @default.
- W2045989867 cites W2136512679 @default.
- W2045989867 cites W2147343083 @default.
- W2045989867 cites W2168190391 @default.
- W2045989867 cites W2169378022 @default.
- W2045989867 cites W2169983584 @default.
- W2045989867 cites W2265745 @default.
- W2045989867 cites W848457211 @default.
- W2045989867 doi "https://doi.org/10.1159/000341403" @default.
- W2045989867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22922609" @default.
- W2045989867 hasPublicationYear "2012" @default.
- W2045989867 type Work @default.
- W2045989867 sameAs 2045989867 @default.
- W2045989867 citedByCount "52" @default.
- W2045989867 countsByYear W20459898672013 @default.
- W2045989867 countsByYear W20459898672014 @default.
- W2045989867 countsByYear W20459898672015 @default.
- W2045989867 countsByYear W20459898672016 @default.
- W2045989867 countsByYear W20459898672017 @default.
- W2045989867 countsByYear W20459898672018 @default.
- W2045989867 countsByYear W20459898672019 @default.
- W2045989867 countsByYear W20459898672020 @default.
- W2045989867 countsByYear W20459898672021 @default.
- W2045989867 countsByYear W20459898672022 @default.
- W2045989867 countsByYear W20459898672023 @default.
- W2045989867 crossrefType "journal-article" @default.
- W2045989867 hasAuthorship W2045989867A5023226419 @default.
- W2045989867 hasAuthorship W2045989867A5029765045 @default.
- W2045989867 hasAuthorship W2045989867A5041865755 @default.
- W2045989867 hasBestOaLocation W20459898671 @default.
- W2045989867 hasConcept C103378370 @default.
- W2045989867 hasConcept C104317684 @default.
- W2045989867 hasConcept C111919701 @default.
- W2045989867 hasConcept C127716648 @default.
- W2045989867 hasConcept C134018914 @default.
- W2045989867 hasConcept C153050134 @default.
- W2045989867 hasConcept C169760540 @default.
- W2045989867 hasConcept C2775841894 @default.
- W2045989867 hasConcept C2775894120 @default.
- W2045989867 hasConcept C2776824294 @default.
- W2045989867 hasConcept C2778961482 @default.
- W2045989867 hasConcept C2779213384 @default.
- W2045989867 hasConcept C41008148 @default.
- W2045989867 hasConcept C54355233 @default.
- W2045989867 hasConcept C86803240 @default.
- W2045989867 hasConceptScore W2045989867C103378370 @default.
- W2045989867 hasConceptScore W2045989867C104317684 @default.
- W2045989867 hasConceptScore W2045989867C111919701 @default.
- W2045989867 hasConceptScore W2045989867C127716648 @default.
- W2045989867 hasConceptScore W2045989867C134018914 @default.
- W2045989867 hasConceptScore W2045989867C153050134 @default.
- W2045989867 hasConceptScore W2045989867C169760540 @default.