FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045992080> ?p ?o ?g. }

• W2045992080 endingPage "959" @default.
• W2045992080 startingPage "956" @default.
• W2045992080 abstract "The mechanism of the synergistic relationship between GH-releasing peptide (GHRP) and GHRH with respect to GH secretion is poorly understood. We report the response to hexarelin, a potent GHRP, in patients affected with a homozygous mutation in the GHRH receptor gene, with consequent GHRH resistance and GH-deficient dwarfism. This newly described syndrome is the human homolog of the little (lit/lit) mouse. Intravenous administration of hexarelin (2 microg/kg) to four male adult patients (dwarfs of Sindh) resulted in a complete lack of elevation in plasma GH levels (< 1 ng/mL), an at least 50- to 100-fold deviation from the normal response. In contrast, plasma PRL, ACTH, and cortisol levels rose in a normal manner in response to hexarelin. We conclude that an intact GHRH signaling system is critical for GHRPs to exert their effect on GH release, but that the GHRH system is not necessary for the effect of GHRP on PRL and ACTH secretion. Hexarelin (and probably other GHRPs) are not effective agents for the treatment of patients with GHRH resistance due to GHRH receptor deficiency." @default.
• W2045992080 created "2016-06-24" @default.
• W2045992080 creator A5009497247 @default.
• W2045992080 creator A5071830224 @default.
• W2045992080 creator A5076549131 @default.
• W2045992080 creator A5082280155 @default.
• W2045992080 date "1999-03-01" @default.
• W2045992080 modified "2023-09-27" @default.
• W2045992080 title "Selective Lack of Growth Hormone (GH) Response to the GH-Releasing Peptide Hexarelin in Patients with GH-Releasing Hormone Receptor Deficiency1" @default.
• W2045992080 cites W1968099447 @default.
• W2045992080 cites W1981695760 @default.
• W2045992080 cites W1984891009 @default.
• W2045992080 cites W1990730347 @default.
• W2045992080 cites W1992400787 @default.
• W2045992080 cites W1992436033 @default.
• W2045992080 cites W1995734405 @default.
• W2045992080 cites W1999831699 @default.
• W2045992080 cites W2017593362 @default.
• W2045992080 cites W2022761976 @default.
• W2045992080 cites W2023173110 @default.
• W2045992080 cites W2035699534 @default.
• W2045992080 cites W2042706359 @default.
• W2045992080 cites W2045059369 @default.
• W2045992080 cites W2046211622 @default.
• W2045992080 cites W2048107602 @default.
• W2045992080 cites W2048625427 @default.
• W2045992080 cites W2051536834 @default.
• W2045992080 cites W2056033709 @default.
• W2045992080 cites W2056240636 @default.
• W2045992080 cites W2057900261 @default.
• W2045992080 cites W2060597901 @default.
• W2045992080 cites W2068309907 @default.
• W2045992080 cites W2071165797 @default.
• W2045992080 cites W2082124734 @default.
• W2045992080 cites W2092835048 @default.
• W2045992080 cites W2126346523 @default.
• W2045992080 cites W2130453289 @default.
• W2045992080 cites W2131266574 @default.
• W2045992080 cites W2158534725 @default.
• W2045992080 cites W2159638671 @default.
• W2045992080 cites W82804727 @default.
• W2045992080 doi "https://doi.org/10.1210/jcem.84.3.5523" @default.
• W2045992080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10084578" @default.
• W2045992080 hasPublicationYear "1999" @default.
• W2045992080 type Work @default.
• W2045992080 sameAs 2045992080 @default.
• W2045992080 citedByCount "26" @default.
• W2045992080 countsByYear W20459920802012 @default.
• W2045992080 countsByYear W20459920802015 @default.
• W2045992080 countsByYear W20459920802018 @default.
• W2045992080 crossrefType "journal-article" @default.
• W2045992080 hasAuthorship W2045992080A5009497247 @default.
• W2045992080 hasAuthorship W2045992080A5071830224 @default.
• W2045992080 hasAuthorship W2045992080A5076549131 @default.
• W2045992080 hasAuthorship W2045992080A5082280155 @default.
• W2045992080 hasBestOaLocation W20459920801 @default.
• W2045992080 hasConcept C104317684 @default.
• W2045992080 hasConcept C126322002 @default.
• W2045992080 hasConcept C134018914 @default.
• W2045992080 hasConcept C170493617 @default.
• W2045992080 hasConcept C185592680 @default.
• W2045992080 hasConcept C2778111144 @default.
• W2045992080 hasConcept C2781042741 @default.
• W2045992080 hasConcept C2984496839 @default.
• W2045992080 hasConcept C49039625 @default.
• W2045992080 hasConcept C55493867 @default.
• W2045992080 hasConcept C56191518 @default.
• W2045992080 hasConcept C71315377 @default.
• W2045992080 hasConcept C71924100 @default.
• W2045992080 hasConceptScore W2045992080C104317684 @default.
• W2045992080 hasConceptScore W2045992080C126322002 @default.
• W2045992080 hasConceptScore W2045992080C134018914 @default.
• W2045992080 hasConceptScore W2045992080C170493617 @default.
• W2045992080 hasConceptScore W2045992080C185592680 @default.
• W2045992080 hasConceptScore W2045992080C2778111144 @default.
• W2045992080 hasConceptScore W2045992080C2781042741 @default.
• W2045992080 hasConceptScore W2045992080C2984496839 @default.
• W2045992080 hasConceptScore W2045992080C49039625 @default.
• W2045992080 hasConceptScore W2045992080C55493867 @default.
• W2045992080 hasConceptScore W2045992080C56191518 @default.
• W2045992080 hasConceptScore W2045992080C71315377 @default.
• W2045992080 hasConceptScore W2045992080C71924100 @default.
• W2045992080 hasIssue "3" @default.
• W2045992080 hasLocation W20459920801 @default.
• W2045992080 hasLocation W20459920802 @default.
• W2045992080 hasOpenAccess W2045992080 @default.
• W2045992080 hasPrimaryLocation W20459920801 @default.
• W2045992080 hasRelatedWork W1982197179 @default.
• W2045992080 hasRelatedWork W1997759048 @default.
• W2045992080 hasRelatedWork W2021502319 @default.
• W2045992080 hasRelatedWork W2045992080 @default.
• W2045992080 hasRelatedWork W2054455773 @default.
• W2045992080 hasRelatedWork W2079613337 @default.
• W2045992080 hasRelatedWork W2081311589 @default.
• W2045992080 hasRelatedWork W2748952813 @default.
• W2045992080 hasRelatedWork W4232843305 @default.
• W2045992080 hasRelatedWork W4241696565 @default.
• W2045992080 hasVolume "84" @default.

• next