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• W2045992133 abstract "The cardiac muscarinic receptor‐K + channel system was reconstructed in Chinese hamster ovary (CHO) cells by transfecting the cells with the various components of the system. The activity of the muscarinic K + channel was measured with the cell‐attached configuration of the patch clamp technique. In CHO cells transfected with the channel (Kir3.1/Kir3.4), receptor (hm2) and receptor kinase (GRK2), on exposure to agonist, there was a decline in channel activity as a result of desensitization, similar to that in atrial cells. Whereas the desensitization was almost abolished by not transfecting with the receptor kinase or by transfecting with a mutant receptor lacking phosphorylation sites, it was only reduced (by ≈39 %) by transfecting with a mutant receptor kinase with little kinase activity. These results suggest that the receptor kinase is responsible for desensitization of the muscarinic K + channel and that this involves phosphorylation‐dependent and ‐independent mechanisms." @default.
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• W2045992133 date "1998-03-01" @default.
• W2045992133 modified "2023-10-16" @default.
• W2045992133 title "Role of receptor kinase in short-term desensitization of cardiac muscarinic K⁺channels expressed in Chinese hamster ovary cells" @default.
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• W2045992133 doi "https://doi.org/10.1111/j.1469-7793.1998.325bt.x" @default.
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