Matches in SemOpenAlex for { <https://semopenalex.org/work/W2045993352> ?p ?o ?g. }
- W2045993352 endingPage "4766" @default.
- W2045993352 startingPage "4756" @default.
- W2045993352 abstract "Akt is constitutively activated in up to 70% of human melanomas and has an important role in the pathogenesis of the disease. However, little is known about protein phosphatases that dephosphorylate and thereby inactivate it in melanoma cells. Here we report that suppression of pleckstrin homology domain and leucine-rich repeat Ser/Thr protein phosphatase 1 (PHLPP1) by DNA methylation promotes Akt activation and has an oncogenic role in melanoma. While it is commonly downregulated, overexpression of PHLPP1 reduces Akt activation and inhibits melanoma cell proliferation in vitro, and retards melanoma growth in a xenograft model. In contrast, knockdown of PHLPP1 increases Akt activation, enhances melanoma cell and melanocyte proliferation, and results in anchorage-independent growth of melanocytes. Suppression of PHLPP1 involves blockade of binding of the transcription factor Sp1 to the PHLPP1 promoter. Collectively, these results suggest that suppression of PHLPP1 by DNA methylation contributes to melanoma development and progression." @default.
- W2045993352 created "2016-06-24" @default.
- W2045993352 creator A5001606920 @default.
- W2045993352 creator A5003787100 @default.
- W2045993352 creator A5019013811 @default.
- W2045993352 creator A5023232472 @default.
- W2045993352 creator A5036757000 @default.
- W2045993352 creator A5041063715 @default.
- W2045993352 creator A5062679563 @default.
- W2045993352 creator A5072813429 @default.
- W2045993352 creator A5080815829 @default.
- W2045993352 creator A5083653505 @default.
- W2045993352 creator A5088905418 @default.
- W2045993352 date "2013-10-14" @default.
- W2045993352 modified "2023-09-27" @default.
- W2045993352 title "Oncogenic suppression of PHLPP1 in human melanoma" @default.
- W2045993352 cites W1970195561 @default.
- W2045993352 cites W1978897662 @default.
- W2045993352 cites W1984879511 @default.
- W2045993352 cites W1986426976 @default.
- W2045993352 cites W1988852924 @default.
- W2045993352 cites W1990353372 @default.
- W2045993352 cites W1990633920 @default.
- W2045993352 cites W1994465394 @default.
- W2045993352 cites W1994987492 @default.
- W2045993352 cites W1995681499 @default.
- W2045993352 cites W2001256555 @default.
- W2045993352 cites W2005438787 @default.
- W2045993352 cites W2006771504 @default.
- W2045993352 cites W2009364489 @default.
- W2045993352 cites W2011901667 @default.
- W2045993352 cites W2012116166 @default.
- W2045993352 cites W2017394604 @default.
- W2045993352 cites W2019047215 @default.
- W2045993352 cites W2021009075 @default.
- W2045993352 cites W2022481874 @default.
- W2045993352 cites W2023543654 @default.
- W2045993352 cites W2024085992 @default.
- W2045993352 cites W2028994134 @default.
- W2045993352 cites W2029729683 @default.
- W2045993352 cites W2030230298 @default.
- W2045993352 cites W2030330538 @default.
- W2045993352 cites W2030808286 @default.
- W2045993352 cites W2032116587 @default.
- W2045993352 cites W2033801757 @default.
- W2045993352 cites W2035258932 @default.
- W2045993352 cites W2039482819 @default.
- W2045993352 cites W2040474954 @default.
- W2045993352 cites W2042185204 @default.
- W2045993352 cites W2043865307 @default.
- W2045993352 cites W2059794606 @default.
- W2045993352 cites W2061988426 @default.
- W2045993352 cites W2073100248 @default.
- W2045993352 cites W2073910094 @default.
- W2045993352 cites W2081295565 @default.
- W2045993352 cites W2084136291 @default.
- W2045993352 cites W2087567111 @default.
- W2045993352 cites W2088467967 @default.
- W2045993352 cites W2092676832 @default.
- W2045993352 cites W2095304369 @default.
- W2045993352 cites W2107744784 @default.
- W2045993352 cites W2109545153 @default.
- W2045993352 cites W2111223585 @default.
- W2045993352 cites W2117028091 @default.
- W2045993352 cites W2121242600 @default.
- W2045993352 cites W2121886536 @default.
- W2045993352 cites W2128542677 @default.
- W2045993352 cites W2128692119 @default.
- W2045993352 cites W2144185275 @default.
- W2045993352 cites W2152606604 @default.
- W2045993352 cites W2152736711 @default.
- W2045993352 cites W2156266404 @default.
- W2045993352 cites W2161018320 @default.
- W2045993352 cites W2161724145 @default.
- W2045993352 cites W2163188200 @default.
- W2045993352 cites W2167076297 @default.
- W2045993352 doi "https://doi.org/10.1038/onc.2013.420" @default.
- W2045993352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24121273" @default.
- W2045993352 hasPublicationYear "2013" @default.
- W2045993352 type Work @default.
- W2045993352 sameAs 2045993352 @default.
- W2045993352 citedByCount "26" @default.
- W2045993352 countsByYear W20459933522015 @default.
- W2045993352 countsByYear W20459933522016 @default.
- W2045993352 countsByYear W20459933522017 @default.
- W2045993352 countsByYear W20459933522018 @default.
- W2045993352 countsByYear W20459933522019 @default.
- W2045993352 countsByYear W20459933522020 @default.
- W2045993352 countsByYear W20459933522021 @default.
- W2045993352 countsByYear W20459933522022 @default.
- W2045993352 countsByYear W20459933522023 @default.
- W2045993352 crossrefType "journal-article" @default.
- W2045993352 hasAuthorship W2045993352A5001606920 @default.
- W2045993352 hasAuthorship W2045993352A5003787100 @default.
- W2045993352 hasAuthorship W2045993352A5019013811 @default.
- W2045993352 hasAuthorship W2045993352A5023232472 @default.
- W2045993352 hasAuthorship W2045993352A5036757000 @default.
- W2045993352 hasAuthorship W2045993352A5041063715 @default.