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- W2045993968 abstract "One of the most common reasons of mortality is cerebral blood supply disturbance, ischemic and hemorrhagic strokes. Although modern pharmacology disposes of a wide range of various remedies effecting different phases of pathologic processes cascade that takes place in case of a stroke, therapy is not always successful; consequences of stroke are particularly difficult in response to treatment. This investigation was carried out with purpose to examine the neuroprotective properties of well known drug Nimodipine and a soluble form of new drug Nooglutyl (N- (5-oxinicotinoyl) l glutamic acid), an agent with nootropic and antihypoxic activity, a positive modulator of AMPA subtype of glutamatergic receptors. The study used new models of intracerebral post-traumatic hematoma (hemorrhagic stroke). Hemorrhagic stroke (HS) was produced in animals by cerebral tissue destruction in the internal capsule region. Nimodipine in dose of 0.1 mg/kg or Nooglutyl in dose of 10 mg/kg was administered i.p. 3–4 h following the operation. It was established that the agents diminished HS-induced neurological deficit, movement co-ordination disturbances. Both preparations were found to prevent the animal death caused by HS. The animals, which were, learned the passive avoidance reflex prior to HS on Day 3 after operation demonstrated disturbances in the retrieval of conditioned passive avoidance reflex (PAR). With Nooglutyl PAR retrieval disorders were much less pronounced. Morphological studies revealed in animals with HS hemorrhages from both sides of the internal capsule, whereas in neurocortex the large amount of neurons with ischemia-induced changes were observed. Nimodipine and in a greater degree Nooglutyl was found to diminish the changes in cortical neurons of rats underwent to HS. The results obtained from these studies provided fair evidence of neuroprotective and memory-restoring properties of Nimodipine and Nooglutyl in a new model of hemorrhagic." @default.
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- W2045993968 date "2009-08-01" @default.
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- W2045993968 title "Neuroprotective effect of nimodipine and nooglutyl in rats with experimentally produced hemorrhagic stroke" @default.
- W2045993968 doi "https://doi.org/10.1016/j.jns.2009.02.170" @default.
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