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- W2045995141 abstract "Gardner's syndrome is an autosomal dominant disorder that predisposes to cancer of the large intestine and to other tumors. We have previously demonstrated that fibroblasts from a patient with this disease are hypersensitive to the cytotoxic effects of ultraviolet light. In this report we have measured several parameters of the repair of ultraviolet light-induced DNA damage in an attempt to identify a defect responsible for the hypersensitivity. We have found the excision rate of pyrimidine dimers, the host cell reactivation of UV-irradiated herpes simplex virus, the induction and rejoining of DNA single strand breaks and the response of semi-conservative DNA replication to UV-irradiation to be in all cases indistinguishable from such phenomena in a variety of normal cells." @default.
- W2045995141 created "2016-06-24" @default.
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- W2045995141 date "1983-12-01" @default.
- W2045995141 modified "2023-09-25" @default.
- W2045995141 title "Normal repair of ultraviolet-induced DNA damage in a hypersensitive strain of fibroblasts from a patient with Gardner's syndrome" @default.
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- W2045995141 doi "https://doi.org/10.1016/0167-8817(83)90031-7" @default.
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