Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046002743> ?p ?o ?g. }
- W2046002743 endingPage "e15433" @default.
- W2046002743 startingPage "e15433" @default.
- W2046002743 abstract "The G protein-coupled estrogen receptor (GPER) is expressed in various tissues including the heart. Since the mRen2.Lewis strain exhibits salt-dependent hypertension and early diastolic dysfunction, we assessed the effects of the GPER agonist (G-1, 40 nmol/kg/hr for 14 days) or vehicle (VEH, DMSO/EtOH) on cardiac function and structure.Intact female mRen2.Lewis rats were fed a normal salt (0.5% sodium; NS) diet or a high salt (4% sodium; HS) diet for 10 weeks beginning at 5 weeks of age.Prolonged intake of HS in mRen2.Lewis females resulted in significantly increased blood pressure, mildly reduced systolic function, and left ventricular (LV) diastolic compliance (as signified by a reduced E deceleration time and E deceleration slope), increased relative wall thickness, myocyte size, and mid-myocardial interstitial and perivascular fibrosis. G-1 administration attenuated wall thickness and myocyte hypertrophy, with nominal effects on blood pressure, LV systolic function, LV compliance and cardiac fibrosis in the HS group. G-1 treatment significantly increased LV lusitropy [early mitral annular descent (e')] independent of prevailing salt, and improved the e'/a' ratio in HS versus NS rats (P<0.05) as determined by tissue Doppler.Activation of GPER improved myocardial relaxation in the hypertensive female mRen2.Lewis rat and reduced cardiac myocyte hypertrophy and wall thickness in those rats fed a high salt diet. Moreover, these advantageous effects of the GPER agonist on ventricular lusitropy and remodeling do not appear to be associated with overt changes in blood pressure." @default.
- W2046002743 created "2016-06-24" @default.
- W2046002743 creator A5070404220 @default.
- W2046002743 creator A5072657419 @default.
- W2046002743 creator A5072715305 @default.
- W2046002743 creator A5077929332 @default.
- W2046002743 creator A5089293982 @default.
- W2046002743 date "2010-11-03" @default.
- W2046002743 modified "2023-10-16" @default.
- W2046002743 title "Attenuation of Salt-Induced Cardiac Remodeling and Diastolic Dysfunction by the GPER Agonist G-1 in Female mRen2.Lewis Rats" @default.
- W2046002743 cites W1509108489 @default.
- W2046002743 cites W1520650580 @default.
- W2046002743 cites W1672412245 @default.
- W2046002743 cites W1966414433 @default.
- W2046002743 cites W1967479320 @default.
- W2046002743 cites W1972520826 @default.
- W2046002743 cites W1981467972 @default.
- W2046002743 cites W1984680535 @default.
- W2046002743 cites W1987928893 @default.
- W2046002743 cites W1999291203 @default.
- W2046002743 cites W1999369965 @default.
- W2046002743 cites W1999894142 @default.
- W2046002743 cites W2009490879 @default.
- W2046002743 cites W2012816393 @default.
- W2046002743 cites W2017884988 @default.
- W2046002743 cites W2018763145 @default.
- W2046002743 cites W2032313594 @default.
- W2046002743 cites W2037514270 @default.
- W2046002743 cites W2040519959 @default.
- W2046002743 cites W2040932618 @default.
- W2046002743 cites W2044059133 @default.
- W2046002743 cites W2044762054 @default.
- W2046002743 cites W2046971992 @default.
- W2046002743 cites W2047043096 @default.
- W2046002743 cites W2054519659 @default.
- W2046002743 cites W2054837968 @default.
- W2046002743 cites W2055502077 @default.
- W2046002743 cites W2056951827 @default.
- W2046002743 cites W2066491496 @default.
- W2046002743 cites W2074933388 @default.
- W2046002743 cites W2081183027 @default.
- W2046002743 cites W2093501112 @default.
- W2046002743 cites W2096858800 @default.
- W2046002743 cites W2106475006 @default.
- W2046002743 cites W2108679157 @default.
- W2046002743 cites W2114936393 @default.
- W2046002743 cites W2116369527 @default.
- W2046002743 cites W2120934972 @default.
- W2046002743 cites W2122246441 @default.
- W2046002743 cites W2141645352 @default.
- W2046002743 cites W2149713530 @default.
- W2046002743 cites W2151524159 @default.
- W2046002743 cites W2151820612 @default.
- W2046002743 cites W2159391743 @default.
- W2046002743 cites W2161185871 @default.
- W2046002743 cites W2168870305 @default.
- W2046002743 cites W2262429621 @default.
- W2046002743 cites W2320615867 @default.
- W2046002743 cites W2334229597 @default.
- W2046002743 cites W2400662394 @default.
- W2046002743 cites W76930537 @default.
- W2046002743 cites W1995526404 @default.
- W2046002743 doi "https://doi.org/10.1371/journal.pone.0015433" @default.
- W2046002743 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2972725" @default.
- W2046002743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21082029" @default.
- W2046002743 hasPublicationYear "2010" @default.
- W2046002743 type Work @default.
- W2046002743 sameAs 2046002743 @default.
- W2046002743 citedByCount "87" @default.
- W2046002743 countsByYear W20460027432012 @default.
- W2046002743 countsByYear W20460027432013 @default.
- W2046002743 countsByYear W20460027432014 @default.
- W2046002743 countsByYear W20460027432015 @default.
- W2046002743 countsByYear W20460027432016 @default.
- W2046002743 countsByYear W20460027432017 @default.
- W2046002743 countsByYear W20460027432018 @default.
- W2046002743 countsByYear W20460027432019 @default.
- W2046002743 countsByYear W20460027432020 @default.
- W2046002743 countsByYear W20460027432021 @default.
- W2046002743 countsByYear W20460027432022 @default.
- W2046002743 countsByYear W20460027432023 @default.
- W2046002743 crossrefType "journal-article" @default.
- W2046002743 hasAuthorship W2046002743A5070404220 @default.
- W2046002743 hasAuthorship W2046002743A5072657419 @default.
- W2046002743 hasAuthorship W2046002743A5072715305 @default.
- W2046002743 hasAuthorship W2046002743A5077929332 @default.
- W2046002743 hasAuthorship W2046002743A5089293982 @default.
- W2046002743 hasBestOaLocation W20460027431 @default.
- W2046002743 hasConcept C121608353 @default.
- W2046002743 hasConcept C126322002 @default.
- W2046002743 hasConcept C134018914 @default.
- W2046002743 hasConcept C166471694 @default.
- W2046002743 hasConcept C167414201 @default.
- W2046002743 hasConcept C207200792 @default.
- W2046002743 hasConcept C530470458 @default.
- W2046002743 hasConcept C57900726 @default.
- W2046002743 hasConcept C71924100 @default.
- W2046002743 hasConcept C84393581 @default.