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• W2046002803 abstract "<b>Objective:</b> To investigate the presenting characteristics of new-onset afebrile seizures in infants (age 1–24 months) and the yield of neuroimaging. <b>Methods:</b> Prospective data were obtained from a standardized evaluation and management plan mandated by a critical care pathway. A total of 317 infants presented with new-onset afebrile seizures between 2001 and 2007. EEG was performed on 90.3%, head CT was obtained on 94%, and MRI was obtained on 57.4%. <b>Results:</b> We found half of the infants had partial features to their seizures, yet evidence for primary generalized seizures was rare. The majority had more than 1 seizure upon presentation. Seizures in this age group tended to be brief, with 44% lasting less than 1 minute. EEG abnormalities were found in half. One-third of CTs were abnormal, with 9% of all CTs requiring acute medical management. Over half of MRIs were abnormal, with cerebral dysgenesis being the most common abnormality (<i>p</i> < 0.05). One-third of normal CTs had a subsequent abnormal MRI—only 1 resulted in altered medical management. <b>Conclusions:</b> Infantile seizures are usually brief, but commonly recurrent, and strong consideration should be made for inpatient observation. Acute imaging with CT can alter management in a small but important number of infants. Due to the superior yield, strong consideration for MRI should be given for all infants, as primary generalized seizures are rare, and there is a high rate of cerebral dysgenesis." @default.
• W2046002803 created "2016-06-24" @default.
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• W2046002803 date "2010-01-11" @default.
• W2046002803 modified "2023-09-26" @default.
• W2046002803 title "New-onset afebrile seizures in infants: Role of neuroimaging" @default.
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• W2046002803 doi "https://doi.org/10.1212/wnl.0b013e3181c91847" @default.
• W2046002803 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2809027" @default.
• W2046002803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20065250" @default.
• W2046002803 hasPublicationYear "2010" @default.
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