FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046003039> ?p ?o ?g. }

• W2046003039 endingPage "2435" @default.
• W2046003039 startingPage "2422" @default.
• W2046003039 abstract "To clarify the extensibility of thin actin and thick myosin filaments in muscle, we examined the spacings of actin and myosin filament-based reflections in x-ray diffraction patterns at high resolution during isometric contraction of frog skeletal muscles and steady lengthening of the active muscles using synchrotron radiation as an intense x-ray source and a storage phosphor plate as a high sensitivity, high resolution area detector. Spacing of the actin meridional reflection at approximately 1/2.7 nm-1, which corresponds to the axial rise per actin subunit in the thin filament, increased about 0.25% during isometric contraction of muscles at full overlap length of thick and thin filaments. The changes in muscles stretched to approximately half overlap of the filaments, when they were scaled linearly up to the full isometric tension, gave an increase of approximately 0.3%. Conversely, the spacing decreased by approximately 0.1% upon activation of muscles at nonoverlap length. Slow stretching of a contracting muscle increased tension and increased this spacing over the isometric contraction value. Scaled up to a 100% tension increase, this corresponds to a approximately 0.26% additional change, consistent with that of the initial isometric contraction. Taken together, the extensibility of the actin filament amounts to 3-4 nm of elongation when a muscle switches from relaxation to maximum isometric contraction. Axial spacings of the layer-line reflections at approximately 1/5.1 nm-1 and approximately 1/5.9 nm-1 corresponding to the pitches of the right- and left-handed genetic helices of the actin filament, showed similar changes to that of the meridional reflection during isometric contraction of muscles at full overlap. The spacing changes of these reflections, which also depend on the mechanical load on the muscle, indicate that elongation is accompanied by slight changes of the actin helical structure possibly because of the axial force exerted by the actomyosin cross-bridges. Additional small spacing changes of the myosin meridional reflections during length changes applied to contracting muscles represented an increase of approximately 0.26% (scaled up to a 100% tension increase) in the myosin periodicity, suggesting that such spacing changes correspond to a tension-related extension of the myosin filaments. Elongation of the myosin filament backbone amounts to approximately 2.1 nm per half sarcomere. The results indicate that a large part (approximately 70%) of the sarcomere compliance of an active muscle is caused by the extensibility of the actin and myosin filaments; 42% of the compliance resides in the actin filaments, and 27% of it is in the myosin filaments." @default.
• W2046003039 created "2016-06-24" @default.
• W2046003039 creator A5013341373 @default.
• W2046003039 creator A5031689366 @default.
• W2046003039 creator A5066899163 @default.
• W2046003039 creator A5084891798 @default.
• W2046003039 creator A5086201173 @default.
• W2046003039 creator A5087467058 @default.
• W2046003039 date "1994-12-01" @default.
• W2046003039 modified "2023-10-13" @default.
• W2046003039 title "X-ray diffraction evidence for the extensibility of actin and myosin filaments during muscle contraction" @default.
• W2046003039 cites W1967796829 @default.
• W2046003039 cites W1980685237 @default.
• W2046003039 cites W1982426004 @default.
• W2046003039 cites W1997246410 @default.
• W2046003039 cites W1997393065 @default.
• W2046003039 cites W2010025052 @default.
• W2046003039 cites W2010777408 @default.
• W2046003039 cites W2021892693 @default.
• W2046003039 cites W2026461827 @default.
• W2046003039 cites W2033028307 @default.
• W2046003039 cites W2039624427 @default.
• W2046003039 cites W2044502834 @default.
• W2046003039 cites W2053510387 @default.
• W2046003039 cites W2060156772 @default.
• W2046003039 cites W2067682517 @default.
• W2046003039 cites W2070037836 @default.
• W2046003039 cites W2070365054 @default.
• W2046003039 cites W2082719075 @default.
• W2046003039 cites W2134594897 @default.
• W2046003039 cites W2415612293 @default.
• W2046003039 cites W2417058495 @default.
• W2046003039 cites W4300325666 @default.
• W2046003039 doi "https://doi.org/10.1016/s0006-3495(94)80729-5" @default.
• W2046003039 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1225627" @default.
• W2046003039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7779179" @default.
• W2046003039 hasPublicationYear "1994" @default.
• W2046003039 type Work @default.
• W2046003039 sameAs 2046003039 @default.
• W2046003039 citedByCount "435" @default.
• W2046003039 countsByYear W20460030392012 @default.
• W2046003039 countsByYear W20460030392013 @default.
• W2046003039 countsByYear W20460030392014 @default.
• W2046003039 countsByYear W20460030392015 @default.
• W2046003039 countsByYear W20460030392016 @default.
• W2046003039 countsByYear W20460030392017 @default.
• W2046003039 countsByYear W20460030392018 @default.
• W2046003039 countsByYear W20460030392019 @default.
• W2046003039 countsByYear W20460030392020 @default.
• W2046003039 countsByYear W20460030392021 @default.
• W2046003039 countsByYear W20460030392022 @default.
• W2046003039 countsByYear W20460030392023 @default.
• W2046003039 crossrefType "journal-article" @default.
• W2046003039 hasAuthorship W2046003039A5013341373 @default.
• W2046003039 hasAuthorship W2046003039A5031689366 @default.
• W2046003039 hasAuthorship W2046003039A5066899163 @default.
• W2046003039 hasAuthorship W2046003039A5084891798 @default.
• W2046003039 hasAuthorship W2046003039A5086201173 @default.
• W2046003039 hasAuthorship W2046003039A5087467058 @default.
• W2046003039 hasBestOaLocation W20460030391 @default.
• W2046003039 hasConcept C103486182 @default.
• W2046003039 hasConcept C105702510 @default.
• W2046003039 hasConcept C12554922 @default.
• W2046003039 hasConcept C125705527 @default.
• W2046003039 hasConcept C134018914 @default.
• W2046003039 hasConcept C14228908 @default.
• W2046003039 hasConcept C15954220 @default.
• W2046003039 hasConcept C163415756 @default.
• W2046003039 hasConcept C185592680 @default.
• W2046003039 hasConcept C192562407 @default.
• W2046003039 hasConcept C2776050358 @default.
• W2046003039 hasConcept C42407357 @default.
• W2046003039 hasConcept C55493867 @default.
• W2046003039 hasConcept C6997183 @default.
• W2046003039 hasConcept C8035138 @default.
• W2046003039 hasConcept C86803240 @default.
• W2046003039 hasConceptScore W2046003039C103486182 @default.
• W2046003039 hasConceptScore W2046003039C105702510 @default.
• W2046003039 hasConceptScore W2046003039C12554922 @default.
• W2046003039 hasConceptScore W2046003039C125705527 @default.
• W2046003039 hasConceptScore W2046003039C134018914 @default.
• W2046003039 hasConceptScore W2046003039C14228908 @default.
• W2046003039 hasConceptScore W2046003039C15954220 @default.
• W2046003039 hasConceptScore W2046003039C163415756 @default.
• W2046003039 hasConceptScore W2046003039C185592680 @default.
• W2046003039 hasConceptScore W2046003039C192562407 @default.
• W2046003039 hasConceptScore W2046003039C2776050358 @default.
• W2046003039 hasConceptScore W2046003039C42407357 @default.
• W2046003039 hasConceptScore W2046003039C55493867 @default.
• W2046003039 hasConceptScore W2046003039C6997183 @default.
• W2046003039 hasConceptScore W2046003039C8035138 @default.
• W2046003039 hasConceptScore W2046003039C86803240 @default.
• W2046003039 hasIssue "6" @default.
• W2046003039 hasLocation W20460030391 @default.
• W2046003039 hasLocation W20460030392 @default.
• W2046003039 hasLocation W20460030393 @default.
• W2046003039 hasLocation W20460030394 @default.
• W2046003039 hasOpenAccess W2046003039 @default.

• next