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• W2046004718 abstract "A susceptibility of promoter DNA for adaptive conformational transitions has been studied using a cationic surfactant dodecyltrimethylammonium bromide (C(12)TAB) as a model DNA-binding ligand. DNAse 1 and KMnO(4) were utilized as structure-specific reagents. Both reagents revealed ligand-induced perturbations in the double helix of promoters T7A1 and T7D. These conformational transitions appeared to be strongly associated with pyrimidine-purine steps, which have non-random distribution within RNA polymerase contact region of the promoter DNA and are present in the binding sites for a majority of transcription regulation proteins. Potential flexibility of these elements creates therefore a specific media for transcription complex formation. Molecular mechanism of DNA interaction with C(12)TAB is discussed." @default.
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• W2046004718 date "2002-04-01" @default.
• W2046004718 modified "2023-09-23" @default.
• W2046004718 title "Flexible Elements in the Structure of Promoter DNA as Probed by Cationic Surfactant Binding" @default.
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• W2046004718 doi "https://doi.org/10.1080/07391102.2002.10506794" @default.
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