FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046008105> ?p ?o ?g. }

• W2046008105 endingPage "795" @default.
• W2046008105 startingPage "786" @default.
• W2046008105 abstract "Nuclear DNA damage has been studied in detail, but much less is known concerning the occurrence and fate of nuclear protein damage. Glycoxidation, protein damage that results from a combination of protein glycation and oxidation, leads to the formation of protein-advanced glycation end products (AGE) of which Nɛ-carboxymethyllysine (CML) is a major AGE. We have used glyoxal, a product of environmental exposures that readily leads to the formation of CML, to study nuclear protein glycoxidation in HaCaT human keratinocytes. Glyoxal treatment that did not affect cell viability but inhibited cell proliferation in a dose-dependent manner that led to accumulation of CML-modified histones. Modified histones were slowly degraded but persisted for more than 3 days following treatment. Preincubation of cells with a proteasome inhibitor following glyoxal treatment led to an increase in CML-modified histones. While glyoxal treatment resulted in a slight decrease in total cellular proteasome activity, a dose dependent increase of up to 4-fold in nuclear proteasome activity was observed. The increase in nuclear proteasome activity was due to both increased nuclear proteasome protein content and increased activity, neither of which were affected by cyclohexamide. The increase also was unaffected by inhibitors of poly(ADP-ribose) polymerases, which have been previously implicated in nuclear proteasome activation by oxidizing agents. Accumulation of CML-modified histones over time may lead to epigenetic changes that contribute to various pathologies including aging and cancer, and upregulation of nuclear proteasome activity under conditions of glyoxidative stress may function to limit such damage." @default.
• W2046008105 created "2016-06-24" @default.
• W2046008105 creator A5021191777 @default.
• W2046008105 creator A5038615104 @default.
• W2046008105 creator A5062608715 @default.
• W2046008105 creator A5065231814 @default.
• W2046008105 date "2005-03-01" @default.
• W2046008105 modified "2023-09-23" @default.
• W2046008105 title "Nuclear proteasome activation and degradation of carboxymethylated histones in human keratinocytes following glyoxal treatment" @default.
• W2046008105 cites W1531318383 @default.
• W2046008105 cites W1968003131 @default.
• W2046008105 cites W1985886590 @default.
• W2046008105 cites W1988775004 @default.
• W2046008105 cites W1992371543 @default.
• W2046008105 cites W1993736540 @default.
• W2046008105 cites W2002698073 @default.
• W2046008105 cites W2008219736 @default.
• W2046008105 cites W2015930146 @default.
• W2046008105 cites W2016360925 @default.
• W2046008105 cites W2017214714 @default.
• W2046008105 cites W2021538179 @default.
• W2046008105 cites W2025771789 @default.
• W2046008105 cites W2030234335 @default.
• W2046008105 cites W2050273469 @default.
• W2046008105 cites W2050617471 @default.
• W2046008105 cites W2051612655 @default.
• W2046008105 cites W2052681712 @default.
• W2046008105 cites W2053622356 @default.
• W2046008105 cites W2058428802 @default.
• W2046008105 cites W2063266199 @default.
• W2046008105 cites W2063431775 @default.
• W2046008105 cites W2070038654 @default.
• W2046008105 cites W2077868873 @default.
• W2046008105 cites W2080202357 @default.
• W2046008105 cites W2085780393 @default.
• W2046008105 cites W2086961233 @default.
• W2046008105 cites W2092263511 @default.
• W2046008105 cites W2093068595 @default.
• W2046008105 cites W2098939161 @default.
• W2046008105 cites W2107613496 @default.
• W2046008105 cites W2145250892 @default.
• W2046008105 cites W2155845629 @default.
• W2046008105 cites W2168937983 @default.
• W2046008105 cites W2237167760 @default.
• W2046008105 cites W4243131973 @default.
• W2046008105 doi "https://doi.org/10.1016/j.freeradbiomed.2004.11.030" @default.
• W2046008105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15721989" @default.
• W2046008105 hasPublicationYear "2005" @default.
• W2046008105 type Work @default.
• W2046008105 sameAs 2046008105 @default.
• W2046008105 citedByCount "39" @default.
• W2046008105 countsByYear W20460081052012 @default.
• W2046008105 countsByYear W20460081052013 @default.
• W2046008105 countsByYear W20460081052014 @default.
• W2046008105 countsByYear W20460081052015 @default.
• W2046008105 countsByYear W20460081052016 @default.
• W2046008105 countsByYear W20460081052018 @default.
• W2046008105 countsByYear W20460081052020 @default.
• W2046008105 countsByYear W20460081052021 @default.
• W2046008105 countsByYear W20460081052023 @default.
• W2046008105 crossrefType "journal-article" @default.
• W2046008105 hasAuthorship W2046008105A5021191777 @default.
• W2046008105 hasAuthorship W2046008105A5038615104 @default.
• W2046008105 hasAuthorship W2046008105A5062608715 @default.
• W2046008105 hasAuthorship W2046008105A5065231814 @default.
• W2046008105 hasConcept C104317684 @default.
• W2046008105 hasConcept C118995209 @default.
• W2046008105 hasConcept C127561419 @default.
• W2046008105 hasConcept C143425029 @default.
• W2046008105 hasConcept C147990577 @default.
• W2046008105 hasConcept C170493617 @default.
• W2046008105 hasConcept C178790620 @default.
• W2046008105 hasConcept C185592680 @default.
• W2046008105 hasConcept C202751555 @default.
• W2046008105 hasConcept C25602115 @default.
• W2046008105 hasConcept C27740335 @default.
• W2046008105 hasConcept C2777603720 @default.
• W2046008105 hasConcept C2778367456 @default.
• W2046008105 hasConcept C29512474 @default.
• W2046008105 hasConcept C2992195973 @default.
• W2046008105 hasConcept C552990157 @default.
• W2046008105 hasConcept C55493867 @default.
• W2046008105 hasConcept C64927066 @default.
• W2046008105 hasConcept C86339819 @default.
• W2046008105 hasConcept C86803240 @default.
• W2046008105 hasConcept C95444343 @default.
• W2046008105 hasConceptScore W2046008105C104317684 @default.
• W2046008105 hasConceptScore W2046008105C118995209 @default.
• W2046008105 hasConceptScore W2046008105C127561419 @default.
• W2046008105 hasConceptScore W2046008105C143425029 @default.
• W2046008105 hasConceptScore W2046008105C147990577 @default.
• W2046008105 hasConceptScore W2046008105C170493617 @default.
• W2046008105 hasConceptScore W2046008105C178790620 @default.
• W2046008105 hasConceptScore W2046008105C185592680 @default.
• W2046008105 hasConceptScore W2046008105C202751555 @default.
• W2046008105 hasConceptScore W2046008105C25602115 @default.
• W2046008105 hasConceptScore W2046008105C27740335 @default.
• W2046008105 hasConceptScore W2046008105C2777603720 @default.

• next