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- W2046008643 abstract "The objective of this work is the investigation of linear acoustic response of three types of ultrasound contrast agents (UCAs) made from poly (vinyl alcohol) (PVA) shelled microbubbles synthesized under varied pH and temperature conditions. Backscattered power, attenuation coefficient and phase velocity of ultrasonic waves propagating through suspensions of UCAs were measured in a frequency range from 3 MHz to 13 MHz and temperature range between 24°C and 37°C. The backscattered power was enhanced up to 20 dB and displayed a weak dependence on temperature. Attenuation and phase velocity, on the other hand, showed higher sensitivity to temperature variations. A modified version of the Church model was developed to estimate the complex frequency dependent viscoelastic modulus of the polymeric shells by means of simultaneously fitting the attenuation and phase velocity data at 24 °C. The dispersion of the storage modulus was found to be typical of semiflexible polymeric networks. On the other hand, the dispersion of the dynamic loss modulus suggests that additional mechanisms, which may be related to the lower dimensionality of the polymeric networks of these shells and/or to spatially non-homogeneous deformations, may play a significant role in the dissipation of the acoustic energy. For the microbubbles of interest, this model predicts frequency dependent resonance frequency higher than 100 MHz." @default.
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- W2046008643 date "2009-08-01" @default.
- W2046008643 modified "2023-10-02" @default.
- W2046008643 title "1499: Assessment of Acoustical and Mechanical Properties of PVA-Shelled Ultrasound Contrast Agents" @default.
- W2046008643 doi "https://doi.org/10.1016/j.ultrasmedbio.2009.06.885" @default.
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