FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046012912> ?p ?o ?g. }

• W2046012912 endingPage "197" @default.
• W2046012912 startingPage "192" @default.
• W2046012912 abstract "The present study was performed to establish whether sequential determinations of antipyrine clearance, using a simplified two-point test, are sensitive and specific indicators of changes in chronic hepatitis B disease activity. Sixteen patients were studied on four or more occasions during 18 to 30 months. Eleven patients were treated with recombinant human α-interferon (2.5, 5.0 or 10 × 106 per m2, intramuscularly, three times per week, for 24 weeks), and five patients were untreated controls. Among seven patients, (six interferon-treated and one control) who lost hepatitis B e antigen from serum, antipyrine clearance improved by 46% (range: 20 to 160%) from 0.37 ± 0.14 ml per kg per min (mean ± S.D.) to 0.54 ± 0.13 ml per kg per min, p < 0.005. This change paralleled the loss of symptoms and reduction of serum ALT levels (from 206 ± 189 IU per liter (mean ± S.D.) to 38 ± 12 IU per liter, p < 0.005). Conversely, antipyrine clearance declined to previous levels when reactivation of chronic hepatitis B with reappearance of HBeAg in serum occurred. Regardless of changes in hepatitis B serology, when serum ALT values fluctuated by more than 20% (presumed to reflect fluctuations in necroinflammatory activity of the liver disease), antipyrine clearance also changed whereas serum albumin and bilirubin concentrations and prothrombin time did not. It is concluded that antipyrine clearance is a more sensitive and specific parameter than conventional indices for assessing hepatic metabolic function during changes in chronic hepatitis B disease activity. Remission in disease with loss of HBeAg from serum is associated with improved hepatic metabolic function as determined by the antipyrine clearance test." @default.
• W2046012912 created "2016-06-24" @default.
• W2046012912 creator A5009028601 @default.
• W2046012912 creator A5074255400 @default.
• W2046012912 date "1989-08-01" @default.
• W2046012912 modified "2023-09-27" @default.
• W2046012912 title "Serial antipyrine clearance studies detect altered hepatic metabolic function during spontaneous and interferon-induced changes in chronic hepatitis B disease activity" @default.
• W2046012912 cites W1501675342 @default.
• W2046012912 cites W1581971337 @default.
• W2046012912 cites W1759046477 @default.
• W2046012912 cites W1815340666 @default.
• W2046012912 cites W1880062466 @default.
• W2046012912 cites W1963875503 @default.
• W2046012912 cites W1980323412 @default.
• W2046012912 cites W1983104590 @default.
• W2046012912 cites W1989483691 @default.
• W2046012912 cites W1998827313 @default.
• W2046012912 cites W2006226407 @default.
• W2046012912 cites W2006242328 @default.
• W2046012912 cites W2009395624 @default.
• W2046012912 cites W2009482238 @default.
• W2046012912 cites W2013011089 @default.
• W2046012912 cites W2020238002 @default.
• W2046012912 cites W2022619776 @default.
• W2046012912 cites W2023437376 @default.
• W2046012912 cites W2051070783 @default.
• W2046012912 cites W2061208588 @default.
• W2046012912 cites W2061490988 @default.
• W2046012912 cites W2061899783 @default.
• W2046012912 cites W2063885826 @default.
• W2046012912 cites W2064775950 @default.
• W2046012912 cites W2075263773 @default.
• W2046012912 cites W2075608793 @default.
• W2046012912 cites W2077438193 @default.
• W2046012912 cites W2078035139 @default.
• W2046012912 cites W2107910568 @default.
• W2046012912 cites W2133012511 @default.
• W2046012912 cites W2180453920 @default.
• W2046012912 cites W2402079146 @default.
• W2046012912 cites W2414382084 @default.
• W2046012912 cites W2415055887 @default.
• W2046012912 cites W4240255828 @default.
• W2046012912 cites W4317563882 @default.
• W2046012912 cites W88942747 @default.
• W2046012912 doi "https://doi.org/10.1002/hep.1840100212" @default.
• W2046012912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2744731" @default.
• W2046012912 hasPublicationYear "1989" @default.
• W2046012912 type Work @default.
• W2046012912 sameAs 2046012912 @default.
• W2046012912 citedByCount "30" @default.
• W2046012912 crossrefType "journal-article" @default.
• W2046012912 hasAuthorship W2046012912A5009028601 @default.
• W2046012912 hasAuthorship W2046012912A5074255400 @default.
• W2046012912 hasConcept C126322002 @default.
• W2046012912 hasConcept C134018914 @default.
• W2046012912 hasConcept C165616093 @default.
• W2046012912 hasConcept C176674119 @default.
• W2046012912 hasConcept C203014093 @default.
• W2046012912 hasConcept C2776029263 @default.
• W2046012912 hasConcept C2776125364 @default.
• W2046012912 hasConcept C2776178377 @default.
• W2046012912 hasConcept C2777075537 @default.
• W2046012912 hasConcept C2777214474 @default.
• W2046012912 hasConcept C2777513400 @default.
• W2046012912 hasConcept C2779102576 @default.
• W2046012912 hasConcept C2992208098 @default.
• W2046012912 hasConcept C41260117 @default.
• W2046012912 hasConcept C512861765 @default.
• W2046012912 hasConcept C71924100 @default.
• W2046012912 hasConcept C90924648 @default.
• W2046012912 hasConceptScore W2046012912C126322002 @default.
• W2046012912 hasConceptScore W2046012912C134018914 @default.
• W2046012912 hasConceptScore W2046012912C165616093 @default.
• W2046012912 hasConceptScore W2046012912C176674119 @default.
• W2046012912 hasConceptScore W2046012912C203014093 @default.
• W2046012912 hasConceptScore W2046012912C2776029263 @default.
• W2046012912 hasConceptScore W2046012912C2776125364 @default.
• W2046012912 hasConceptScore W2046012912C2776178377 @default.
• W2046012912 hasConceptScore W2046012912C2777075537 @default.
• W2046012912 hasConceptScore W2046012912C2777214474 @default.
• W2046012912 hasConceptScore W2046012912C2777513400 @default.
• W2046012912 hasConceptScore W2046012912C2779102576 @default.
• W2046012912 hasConceptScore W2046012912C2992208098 @default.
• W2046012912 hasConceptScore W2046012912C41260117 @default.
• W2046012912 hasConceptScore W2046012912C512861765 @default.
• W2046012912 hasConceptScore W2046012912C71924100 @default.
• W2046012912 hasConceptScore W2046012912C90924648 @default.
• W2046012912 hasIssue "2" @default.
• W2046012912 hasLocation W20460129121 @default.
• W2046012912 hasLocation W20460129122 @default.
• W2046012912 hasOpenAccess W2046012912 @default.
• W2046012912 hasPrimaryLocation W20460129121 @default.
• W2046012912 hasRelatedWork W146511002 @default.
• W2046012912 hasRelatedWork W2077100277 @default.
• W2046012912 hasRelatedWork W2079281353 @default.
• W2046012912 hasRelatedWork W2142646860 @default.
• W2046012912 hasRelatedWork W2354581436 @default.
• W2046012912 hasRelatedWork W2381085530 @default.

• next