FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046025026> ?p ?o ?g. }

• W2046025026 endingPage "705" @default.
• W2046025026 startingPage "704a" @default.
• W2046025026 abstract "Back to table of contents Previous article Next article Book ForumFull AccessThe Pharmacology of Alcohol and Alcohol DependenceJOSEPH WESTERMEYER, M.D., PH.D., JOSEPH WESTERMEYERSearch for more papers by this author, M.D., PH.D., Minneapolis, Minn.Published Online:1 May 1998https://doi.org/10.1176/ajp.155.5.704aAboutSectionsView EPUB ToolsAdd to favoritesDownload CitationsTrack Citations ShareShare onFacebookTwitterLinked InEmail This book comprises up-to-date reviews of the basic pharmacology of alcoholism, prepared by leading investigators. Well-referenced chapters cover such important topics as brain imaging research, electrophysiological activity, and autonomic nervous system findings associated with alcohol use and abuse. Studies on physical dependence, tolerance, and withdrawal are well covered, as well as the effects of alcohol on calcium and other ion channels, γ-aminobutyric acid, the excitatory amines, and neurotransmitters. Other eminently readable topics include cross-tolerance and stroke among alcohol abusers.Most research cited involved animal models, especially mice and rats, as well as in vitro cell preparations. These research findings are generally based on indirect rather than on direct measures. Thus, the investigators have had to be both careful and creative.As noted by Deitrich and co-authors on page 458, pharmacological agents have often been used for studies on the basis of clinical observations of humans, rather than the reverse. Consequently, application to humans has long predated most of the research efforts described. Despite decades of research, clinical applications (or even implications) are sparse.Numerous statements throughout the book reveal the differing perspectives of basic and clinical students of alcoholism. A few examples from the opening pages follow:In their preface, the editors begin, “The pharmacology of alcohol was the first area to be studied by alcohol researchers,” although clinical researchers began making cogent observations on alcoholism centuries ago (1).On page 4, the authors appear to lend considerable credence to the concept of “primary psychological dependence,” although addiction psychiatrists abandoned the term a few decades ago. Also on page 4, the authors state (without citation) that 15% of untreated delirium tremens cases result in death. The rate could be much higher or, perhaps, lower depending on the definition of “untreated.”These discordant statements, together with the clinical irrelevance of much research in this area, call for a greater collaboration between those funding, designing, and conducting such research and those facing “real world” clinical and public health problems.In sum, this volume provides excellent summaries of the research on the pharmacology of alcohol and alcoholism conducted over the last few decades. Forensic psychiatrists dealing with cases involving alcohol would gain from reviewing the latest data on human cases and studies (especially the chapter by Kalant). Practicing psychiatrists, including those in addiction psychiatry, will find little to help them with their clinical tasks.edited by Henri Begleiter, and Benjamin Kissin. New York, Oxford University Press, 1996, 506 pp., $99.50.References1 Rodin AE: Infants and gin mania in 18th century London. JAMA 1981; 245:1237–1239Crossref, Medline, Google Scholar FiguresReferencesCited byDetailsCited ByNone Volume 155Issue 5 May 1998Pages 704a-705 Metrics History Published online 1 May 1998 Published in print 1 May 1998" @default.
• W2046025026 created "2016-06-24" @default.
• W2046025026 creator A5091366131 @default.
• W2046025026 date "1998-05-01" @default.
• W2046025026 modified "2023-09-26" @default.
• W2046025026 title "The Pharmacology of Alcohol and Alcohol Dependence" @default.
• W2046025026 doi "https://doi.org/10.1176/ajp.155.5.704a" @default.
• W2046025026 hasPublicationYear "1998" @default.
• W2046025026 type Work @default.
• W2046025026 sameAs 2046025026 @default.
• W2046025026 citedByCount "0" @default.
• W2046025026 crossrefType "journal-article" @default.
• W2046025026 hasAuthorship W2046025026A5091366131 @default.
• W2046025026 hasConcept C118552586 @default.
• W2046025026 hasConcept C15744967 @default.
• W2046025026 hasConcept C169760540 @default.
• W2046025026 hasConcept C185592680 @default.
• W2046025026 hasConcept C2780931562 @default.
• W2046025026 hasConcept C2781066024 @default.
• W2046025026 hasConcept C55493867 @default.
• W2046025026 hasConcept C71924100 @default.
• W2046025026 hasConceptScore W2046025026C118552586 @default.
• W2046025026 hasConceptScore W2046025026C15744967 @default.
• W2046025026 hasConceptScore W2046025026C169760540 @default.
• W2046025026 hasConceptScore W2046025026C185592680 @default.
• W2046025026 hasConceptScore W2046025026C2780931562 @default.
• W2046025026 hasConceptScore W2046025026C2781066024 @default.
• W2046025026 hasConceptScore W2046025026C55493867 @default.
• W2046025026 hasConceptScore W2046025026C71924100 @default.
• W2046025026 hasIssue "5" @default.
• W2046025026 hasLocation W20460250261 @default.
• W2046025026 hasOpenAccess W2046025026 @default.
• W2046025026 hasPrimaryLocation W20460250261 @default.
• W2046025026 hasRelatedWork W1971842759 @default.
• W2046025026 hasRelatedWork W1978144529 @default.
• W2046025026 hasRelatedWork W1990613653 @default.
• W2046025026 hasRelatedWork W2045485681 @default.
• W2046025026 hasRelatedWork W2069417882 @default.
• W2046025026 hasRelatedWork W2082702637 @default.
• W2046025026 hasRelatedWork W2748952813 @default.
• W2046025026 hasRelatedWork W2899084033 @default.
• W2046025026 hasRelatedWork W97374268 @default.
• W2046025026 hasRelatedWork W125274287 @default.
• W2046025026 hasVolume "155" @default.
• W2046025026 isParatext "false" @default.
• W2046025026 isRetracted "false" @default.
• W2046025026 magId "2046025026" @default.
• W2046025026 workType "article" @default.