Matches in SemOpenAlex for { <https://semopenalex.org/work/W2046027318> ?p ?o ?g. }
- W2046027318 endingPage "1046" @default.
- W2046027318 startingPage "1037" @default.
- W2046027318 abstract "Colorectal carcinoma is uncommon in Egypt, but a high proportion of cases occurs before age 40 years and in the rectum. We compared the molecular pathology of 59 representative Egyptian patients aged 10–72 to Western patients with sporadic, young-onset, or hereditary non-polyposis colorectal cancer syndrome (HNPCC)-associated carcinoma and found significant differences. Most Egyptian cancers were rectal (51%) and poorly differentiated (58%). High levels of microsatellite instability (MSI-H) were frequent (37%) and attributable in some cases (36%) to methylation of the promoter of the hMLH1 mismatch repair gene, but no MSI-H cancer had loss of hMSH2 mismatch repair gene product of the type seen with germline hMSH2 mutation in HNPCC. K-ras mutation was uncommon (11%). In subset analyses, high frequencies of MSI-H in rectal carcinomas (36%) and p53 gene product overexpression in MSI-H cancers (50%) were found. MSI-H and K-ras mutation in Egyptians under age 40 were unusual (17% and 0%, respectively), and schistosomiasis was associated with MSI and K-ras mutation. Cluster analysis identified 2 groups: predominantly young men with poorly differentiated mucinous and signet-ring cell colorectal carcinoma lacking K-ras mutation; older patients who had well- or moderately differentiated adenocarcinoma often with MSI-H, K-ras mutation and schistosomiasis. Our findings show that the molecular pathology of colorectal cancer in older as well as younger Egyptians has unique differences from Western patients, and schistosomiasis influences the molecular pathogenesis of some tumours. © 2001 Cancer Research Campaign http://www.bjcancer.com" @default.
- W2046027318 created "2016-06-24" @default.
- W2046027318 creator A5001172041 @default.
- W2046027318 creator A5006615775 @default.
- W2046027318 creator A5006802038 @default.
- W2046027318 creator A5012085802 @default.
- W2046027318 creator A5012210223 @default.
- W2046027318 creator A5018278944 @default.
- W2046027318 creator A5027839397 @default.
- W2046027318 creator A5039354089 @default.
- W2046027318 creator A5061350277 @default.
- W2046027318 creator A5063141720 @default.
- W2046027318 creator A5063317904 @default.
- W2046027318 creator A5072927901 @default.
- W2046027318 creator A5077617292 @default.
- W2046027318 creator A5078636533 @default.
- W2046027318 creator A5089590234 @default.
- W2046027318 date "2001-09-01" @default.
- W2046027318 modified "2023-10-16" @default.
- W2046027318 title "Contrasting molecular pathology of colorectal carcinoma in Egyptian and Western patients" @default.
- W2046027318 cites W149099508 @default.
- W2046027318 cites W1493757126 @default.
- W2046027318 cites W1499941079 @default.
- W2046027318 cites W1509452950 @default.
- W2046027318 cites W1513040830 @default.
- W2046027318 cites W1544851750 @default.
- W2046027318 cites W1568498267 @default.
- W2046027318 cites W1663072708 @default.
- W2046027318 cites W1918173167 @default.
- W2046027318 cites W1961988123 @default.
- W2046027318 cites W1966957822 @default.
- W2046027318 cites W1968748902 @default.
- W2046027318 cites W1969231537 @default.
- W2046027318 cites W1970064594 @default.
- W2046027318 cites W1971939914 @default.
- W2046027318 cites W1972719523 @default.
- W2046027318 cites W1977048390 @default.
- W2046027318 cites W1979056927 @default.
- W2046027318 cites W1984439054 @default.
- W2046027318 cites W1984887162 @default.
- W2046027318 cites W1986937402 @default.
- W2046027318 cites W1988564496 @default.
- W2046027318 cites W1989305101 @default.
- W2046027318 cites W1991494214 @default.
- W2046027318 cites W1991891005 @default.
- W2046027318 cites W1994465394 @default.
- W2046027318 cites W1996588062 @default.
- W2046027318 cites W2001677846 @default.
- W2046027318 cites W2005701686 @default.
- W2046027318 cites W2011673642 @default.
- W2046027318 cites W2012063444 @default.
- W2046027318 cites W2015599105 @default.
- W2046027318 cites W2017017512 @default.
- W2046027318 cites W2019008551 @default.
- W2046027318 cites W2021287246 @default.
- W2046027318 cites W2022057128 @default.
- W2046027318 cites W2022518535 @default.
- W2046027318 cites W2029862426 @default.
- W2046027318 cites W2032930680 @default.
- W2046027318 cites W2035524762 @default.
- W2046027318 cites W2039464396 @default.
- W2046027318 cites W2040054920 @default.
- W2046027318 cites W2055656665 @default.
- W2046027318 cites W2056122592 @default.
- W2046027318 cites W2056896539 @default.
- W2046027318 cites W2057962064 @default.
- W2046027318 cites W2059657066 @default.
- W2046027318 cites W2062598736 @default.
- W2046027318 cites W2063579751 @default.
- W2046027318 cites W2065045375 @default.
- W2046027318 cites W2072933771 @default.
- W2046027318 cites W2073525854 @default.
- W2046027318 cites W2082040301 @default.
- W2046027318 cites W2087240355 @default.
- W2046027318 cites W2088098884 @default.
- W2046027318 cites W2093531978 @default.
- W2046027318 cites W2098349703 @default.
- W2046027318 cites W2102730613 @default.
- W2046027318 cites W2107972234 @default.
- W2046027318 cites W2113215973 @default.
- W2046027318 cites W2115047855 @default.
- W2046027318 cites W2118587067 @default.
- W2046027318 cites W2123927174 @default.
- W2046027318 cites W2133462388 @default.
- W2046027318 cites W2134337203 @default.
- W2046027318 cites W2134554242 @default.
- W2046027318 cites W2147755808 @default.
- W2046027318 cites W2152111302 @default.
- W2046027318 cites W2152186092 @default.
- W2046027318 cites W2154546296 @default.
- W2046027318 cites W2162318702 @default.
- W2046027318 cites W2163656748 @default.
- W2046027318 cites W2168103024 @default.
- W2046027318 cites W2170801337 @default.
- W2046027318 cites W2302923023 @default.
- W2046027318 cites W2408100331 @default.
- W2046027318 cites W2441297594 @default.
- W2046027318 cites W3143569680 @default.